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NR-4282   Monoclonal Anti-Influenza A Virus Nucleoprotein (NP), Clones A1 and A3 (ascites blend, Mouse)
(Monoclonal Antibodies)
Description: Monoclonal Anti-Influenza A Virus Nucleoprotein (NP), Clones A1 and A3 (ascites blend, Mouse)
Organism: Influenza A virus
Biosafety Level: 1
Availability Status: In Stock
Store at: -20°C to -40°C
Contributor: NIH Biodefense and Emerging Infections Research Resources Repository
Comments:
Quantity limit per order for this item is 5. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

Lot No. 7701149

Antibody Class: IgG2a (A1); IgG1 (A3)

Mouse monoclonal antibodies specific to the nucleoprotein (NP) of influenza A virus derived from hybridoma A1 and A3 clones were produced separately in mouse ascites and blended (1:1).

All viruses with negative-sense RNA genomes encode a single-strand RNA-binding NP. The primary function of NP is to encapsidate the virus genome for the purposes of RNA transcription, replication and packaging. NP serves as the structural protein in ribonucleoprotein particles and has been proposed to contain at least two different nuclear localization signals (NLS): an unconventional NLS, necessary for efficient synthesis of viral mRNA, and a bipartite NLS, which is essential for viral replication, likely due to its role in vRNA transcription. The crystal structure of influenza A virus NP (strain A/WSN/1933) has recently been determined (PDB: 2IQH).

Each vial of NR-4282 contains blended and lyophilized (0.5 mL containing no preservatives) mouse ascites fluid.

Citations: Acknowledgment for publications should read "The following reagent was obtained through the NIH Biodefense and Emerging Infections Research Resources Repository, NIAID, NIH: Monoclonal Anti-Influenza A Virus Nucleoprotein (NP), Clones A1 and A3 (ascites blend, Mouse), NR-4282."
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