TARGET Research Results
Details
DescriptionISOCITRATE LYASE ICL (ISOCITRASE) (ISOCITRATASE)
Accession numberRv0467
Gene nameicl
Gene length1287
Protein length428
Coordinates557527..558813
Orientation+
Molecular mass47086.48
Isoelectric point4.79

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU0467-1[no data]
JHU0467-266[no data]
JHU0467-1118[no data]
 

CDC1551 Homolog
ORFMT0483
Essentiality Prediction
Sassetti et al, 2003*[no data]

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU0467-1MT0483Rv046711287yes
JHU0467-266MT0483Rv04672661287no (will be available later)
JHU0467-1118MT0483Rv046711181287no (will be available later)
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]