TARGET Research Results
Details
DescriptionGDP-D-mannose dehydratase gmdA (GDP-mannose 4,6 dehydratase) (GMD)
Accession numberRv1511
Gene namegmdA
Gene length1023
Protein length340
Coordinates1703074..1704096
Orientation+
Molecular mass38310.24
Isoelectric point6.52

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU1511-69Not-Attenuated
JHU1511-204[no data]
JHU1511-271[no data]
 

CDC1551 Homolog
ORFMT1561
Essentiality Prediction
Sassetti et al, 2003*[no data]

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU1511-204MT1561Rv15112041047yes
JHU1511-271MT1561Rv15112711047no (will be available later)
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]