TARGET Research Results
Details
DescriptionPROBABLE ATP-DEPENDENT HELICASE LHR (LARGE HELICASE-RELATED PROTEIN)
Accession numberRv3296
Gene namelhr
Gene length4542
Protein length1513
Coordinates3676775..3681316
Orientation+
Molecular mass161347.23
Isoelectric point6.62

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU3296-631Not-Attenuated
JHU3296-193[no data]
JHU3296-2601[no data]
JHU3296-2457[no data]
JHU3296-1919[no data]
 

CDC1551 Homolog
ORFMT3395
Essentiality Prediction
Sassetti et al, 2003*[no data]

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU3296-193MT3395Rv32961934542yes
JHU3296-2601MT3395Rv329626014542no (will be available later)
JHU3296-1919MT3395Rv329619194542yes
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]