TARGET Research Results
Details
DescriptionPROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE MHPE (HOA)
Accession numberRv3469c
Gene namemhpE
Gene length1011
Protein length336
Coordinates3886073..3887083
Orientation-
Molecular mass36297.03
Isoelectric point5.36

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU3469c-59[no data]
JHU3469c-326[no data]
JHU3469c-326Not-Attenuated
JHU3469c-326Not-Attenuated
 

CDC1551 Homolog
ORFMT3575
Essentiality Prediction
Sassetti et al, 2003*[no data]

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU3469c-59MT3575Rv3469c591005no (will be available later)
JHU3469c-326MT3575Rv3469c3261005yes
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]