Resources for Trypanosoma cruzi Research

 

Trypanosoma cruzi (T. cruzi) is the protozoan parasite responsible for Chagas’ disease, a debilitating illness first identified in 1909 that remains a neglected tropical disease in Central and South America where it is endemic.1 T. cruzi has been identified through analysis of vector and climate data as a potential emerging health risk to humans in the southern United States, where the most commonly reported wildlife reservoirs are the raccoon and the Virginia opossum.2,3

Transmission to humans occurs through triatomine insect vectors and can be passed congenitally as well as through blood infusions, organ transplantation and ingestion of contaminated food and water, and often leads to chronic conditions such as myocarditis or meningoencephalitis.1,2,3

The BEI Resources T. cruzi catalog represents human, animal and vector isolates collected in the United States and throughout South America over a span of nearly 50 years. Many of these isolates are also available as transgenic strains, genomic DNA and monoclonal antibodies.

Recent additions of the virulent human strain Brazil are available in epimastigote and trypomastigote forms of the parasite life cycle both with and without luciferase expression, and genomic DNA.

 

BEI Resources 

Trypanosoma cruzi

NR-40347

Trypanosoma cruzi, Strain Brazil (+luc; trypomastigote stage)

NR-46429

Trypanosoma cruzi, Strain Brazil (+luc; axenic epimastigote)

NR-53932

Trypanosoma cruzi, Strain Brazil (axenic epimastigote)

NR-55374

Genomic DNA from Trypanosoma cruzi, Strain Brazil (NR-53932)

NR-55285

Trypanosoma cruzi, Strain Brazil (trypomastigote)

 

 

 

 

 

 

 

 

 

 

References:

  1. Bern, C. "Chagas’ Disease." N. Engl. J. Med. 373 (2015): 456-466. PubMed: 26222561.
  2. Patel, J. M., et al. "Isolation, Mouse Pathogenicity, and Genotyping of Trypanosoma cruzi from an English Cocker Spaniel from Virginia, USA." Vet. Parasitol. 187 (2012): 394-398. PubMed: 22341614.
  3. Garza, M., et al. "Projected Future Distributions of Vectors of Trypanosoma cruzi in North America Under Climate Change Scenarios." PLoS Negl. Trop. Dis. 8 (2014): e2818. PubMed: 24831117.

Image: Photomicrograph of four flagellated Trypanosoma cruzi parasites in a blood sample taken in 1968. (CDC)

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