Multidrug-Resistant Diversity Panels

 

Diversity panels deposited by the Multidrug-Resistant Organism Repository and Surveillance Network (MRSN) within the Bacterial Diseases Branch of the Walter Reed Army Institute are now available. These panels support the research and development of new antibiotics and tools to treat infections caused the opportunistic pathogens Acinetobacter baumanii (A. baumanii) and Pseudomonas aeruginosa (P. aeruginosa).

The A. baumanii MRSN diversity panel represents 70 different traditional Pasteur scheme multilocus sequence types (MLST) and contains 100 distinct alleles encompassing 32 families of antimicrobial resistance genes.1

The P. aeruginosa MRSN diversity panel represents 91 different MLSTs and 88 antimicrobial resistance genes resulting in 71 distinct antibiotic susceptibility profiles.2

Each panel consists of 100 isolates assembled from a larger collection of clinical isolates and contains genetically distinct strains from major epidemic clones with phenotypes ranging from pan-susceptible to pan-resistant. Isolates are fully characterized using whole genome sequencing, complete with antimicrobial-resistant gene content and comprehensive susceptibility profile of clinically relevant antibiotics detailed on the individual documentation available for each isolate.

The P. aeruginosa MRSN diversity panel is available as individual isolates (BEI Resources NR-51515 through NR-51614) and a complete panel of all 100 isolates (NR-51829). The 100 isolates in the A. baumanii MRSN Diversity Panel are available as BEI Resources NR-52148 through NR-52247 and the assembled panel as BEI Resources NR-52248.

 

BEI Resources 

Antibiotic Diversity Panels

NR-51829

Pseudomonas aeruginosa MRSN Diversity Panel

NR-52248

Acinetobacter baumannii MRSN Diversity Panel

 

 

 

 

 

 

 

References:

  1. Galac, M. R., et al. "A Diverse Panel of Clinical Acinetobacter baumannii for Research and Development." Antimicrob. Agents Chemother. 21 (2020): e00840-20. PubMed: 32718956.
  2. Lebreton, F., et al. "A Panel of Diverse Pseudomonas aeruginosa Clinical Isolates for Research and Development." JAC Antimicrob. Resist. 3 (2021): dlab179. PubMed: 34909689.

Image: Antimicrobial susceptibility testing of an Acinetobacter baumannii MRSN strain. (BEI Resources)

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