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Trichomonas vaginalis Clinical Isolates
Trichomonas vaginalis is the most common non-viral sexually transmitted parasite and causative agent of trichomoniasis. Metronidazole is the drug choice for treatment, but in some clinical cases parasites can exhibit resistance.1,2
A 2012 study genotyped over 200 isolates from different countries around the world, including 19 clinical isolates collected from women in New York City.2 Using population genetic analysis, the study showed that T. vaginalis is a genetically diverse parasite with a unique population structure consisting of two genotypes present in equal proportions world-wide. The genotypes differ in the rate at which they harbor the T. vaginalis virus (TVV) and in their sensitivity to metronidazole.
A follow-up study in 2017 sequenced multiple clinical isolates and lab-derived lines and identified additional genetic markers and mechanisms of metronidazole resistance.1 The 2017 study identified 72 SNPs associated with metronidazole resistance. A comparison of SNPs within lab-derived resistant lines revealed an overlap with clinically resistant isolates. The isolates from the 2012 and 2017 studies represent clinical isolates exhibiting different genotypes and metronidazole resistance profiles. The availability of these isolates to the scientific community will be valuable in the execution of drug susceptibility studies and elucidation of the molecular mechanisms involved in T. vaginalis metronidazole resistance.
Additional isolates are currently in process and will be available soon. For timeline availability, please contact us at Contact@BEIResources.org.
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BEI Resources
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Trichomonas vaginalis Clinical Isolates
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| NR-58890 |
Trichomonas vaginalis, Strain NYCA04 |
| NR-58891 |
Trichomonas vaginalis, Strain NYCB20 |
| NR-58892 |
Trichomonas vaginalis, Strain NYCC29 - Coming Soon
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| NR-58893 |
Trichomonas vaginalis, Strain NYCC30 - Coming Soon |
| NR-58894 |
Trichomonas vaginalis, Strain NYCC37 - Coming Soon |
| NR-58896 |
Trichomonas vaginalis, Strain NYCE32clone8 - Coming Soon |
| NR-58897 |
Trichomonas vaginalis, Strain NYCF20 - Coming Soon
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| NR-58899 |
Trichomonas vaginalis, Strain CDC944 - Coming Soon |
References:
1. Bradic, M., et al. “Genetic Indicators of Drug Resistance in the Highly Repetitive Genome of Trichomonas vaginalis.” Genome Biol. Evol. 9 (2017): 1658-1672. PubMed: 28633446. .
1. Conrad, M. D., et al. “Extensive Genetic Diversity, Unique Population Structure and Evidence of Genetic Exchange in the Sexually Transmitted Parasite Trichomonas vaginalis.” PLoS Negl. Trop. Dis. 6 (2012): e1573. PubMed: 22479659.
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