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NR-3476  Influenza A virus, Kilbourne F133: A/New Jersey/11/1976 (HA) x A/Puerto Rico/8/1934 (NA) (H1N1), Low (L) Yield, Reassortant/Mutant X-53 (CL) - PR8(2) H2P4 (L)
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Description: Kilbourne F133: A/New Jersey/11/1976 (HA) x A/Puerto Rico/8/1934 (NA) (H1N1), Low (L) Yield, Reassortant/Mutant X-53 (CL) - PR8(2) H2P4 (L)
Organism: Influenza A virus
Biosafety Level: 2
Availability Status: In Stock
Store at: -60°C or colder
Contributor: NIAID/NIH
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

NR-3476 is a low (L) yield back-revertant of a previously isolated high (H) yield mutant of a reassortant of X-53 (CL)-2 and A/Puerto Rico/8/1934 (H1N1). X-53 (CL)-2 was derived by cloning and passage of X-53 (Kilbourne F128; BEI Resources NR-3664), which is A/New Jersey/11/1976 (HA, NA) x A/Puerto Rico/8/1934 (H1N1). The HA gene of NR-3476 is definitively derived from influenza A/New Jersey/11/1976 (H1N1), a human isolate recovered during the 1976 swine flu epidemic at Fort Dix, NJ. All other genes are from A/Puerto Rico/8/1934 (H1N1). The derivation and properties of various A/New Jersey/11/1976 (H1N1) reassortants, as well as cloned derivatives, mutants, and re-reassortants thereof, have been described in detail. The change from H to L phenotype is associated with a single amino acid change in the HA protein.

Each vial contains approximately 1 mL of pooled allantoic fluid from specific pathogen free (SPF) embryonated chicken eggs infected with reassortant/mutant influenza A virus, A/New Jersey/11/1976 (HA) x A/Puerto Rico/8/1934 (NA) (H1N1), Low (L) Yield.

Kilbourne Archive Homepage
Kilbourne/New York Medical College Archive of Influenza Virus Reassortants and Mutants
Kilbourne F133 information
Download (Word Docs):Detailed Description
File Number:F133
Virus Name:
Virus Attributes:Type A Virus. A subtype H1N1. reassortant. mutant . antigenic (HA/NA) hybrid. human HA-specific antigenic hybrid. high yield reassortants
AntiserumImmunizing VirusLocationAntiserum Attributes
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Kilbourne F133: A/New Jersey/11/1976 (HA) x A/Puerto Rico/8/1934 (NA) (H1N1), Low (L) Yield, Reassortant/Mutant X-53 (CL) - PR8(2) H2P4 (L), NR-3476."
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