Back to My Search

Login is required to view Product Sheets and Certificates of Analysis.

Contact Us   Having technical issues or questions regarding this product?
Please Contact Us.
BEI Resources currently limits the total number of "Made to Order" items which can be ordered by a registrant to 10 "Made to Order" items per 6 month period. Please check the Availability Status on the items you are ordering and limit orders appropriately.
NR-48814   Bat SARS-Like Coronavirus, HKU5, Recombinant, Containing the SARS Coronavirus, Urbani Spike Glycoprotein Ectodomain
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Bat SARS-Like Coronavirus, HKU5, Recombinant, Containing the SARS Coronavirus, Urbani Spike Glycoprotein Ectodomain
Organism: SARS coronavirus
Biosafety Level: 3
Availability Status: In Stock
Store at: -60°C or colder
Contributor: RS Baric
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

Synthetic recombinant bat severe acute respiratory syndrome (SARS)-like coronavirus (CoV), HKU5, containing the spike glycoprotein ectodomain of the SARS-CoV Urbani strain (BtCoV HKU5-SE).

The complete genome of bat CoV HKU5 has been sequenced (GenBank: EF065512), as has the complete genome of SARS-CoV, Urbani (GenBank: AY278741), and a mouse-adapted variant (GenBank: DQ497008).

NR-48814 is a synthetic chimeric recombinant coronavirus based on a consensus bat SARS-like coronavirus (SCoV) sequence. The region of the bat SCoV genome encoding the spike (S) glycoprotein ectodomain was replaced with the corresponding region from the SARS-CoV, Urbani genome. A histidine for tyrosine substitution at position 436, previously shown to enhance replication in mice, was also included in the S gene. This virus replicates efficiently in cell culture and in young and aged mice, where the virus targets airway and alveolar epithelial cells.

Each vial contains approximately 1 mL of cell lysate and supernatant from Cercopithecus aethiops kidney epithelial cells (Vero 76, clone E6: ATCC ® CRL-1586™) infected with BtCoV HKU5-SE.

Use of this material for any purpose by commercial or for profit entities requires a license from The University of North Carolina at Chapel Hill prior to shipment. For more information on obtaining a license to use this material please contact the UNC-CH Office of Technology Development, 100 Europa Drive, Suite 430, Chapel Hill, North Carolina 27517, Phone (919) 966-3929, Email:
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Bat SARS-Like Coronavirus, HKU5, Recombinant, Containing the SARS Coronavirus, Urbani Spike Glycoprotein Ectodomain, NR-48814."
For a list of permits that may be required for shipping this product and to set the permit information preferences; please select a country from the drop down below.

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

Return to Top

Notices and Disclaimers

BEI Resources products are intended for laboratory research purposes only. They are not intended for use in humans.

While BEI Resources uses reasonable efforts to include accurate and up-to-date information on this site, BEI Resources makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. BEI Resources does not warrant that such information has been confirmed to be accurate.

Back to My Search