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NR-48814   Bat SARS-Like Coronavirus, HKU5, Recombinant, Containing the SARS Coronavirus, Urbani Spike Glycoprotein Ectodomain
(Viruses)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Bat SARS-Like Coronavirus, HKU5, Recombinant, Containing the SARS Coronavirus, Urbani Spike Glycoprotein Ectodomain
Organism: SARS coronavirus
Biosafety Level: 3
Availability Status: In Stock
Store at: -60°C or colder
Contributor: RS Baric
Comments:
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

Synthetic recombinant bat severe acute respiratory syndrome (SARS)-like coronavirus (CoV), HKU5, containing the spike glycoprotein ectodomain of the SARS-CoV Urbani strain (BtCoV HKU5-SE).

The complete genome of bat CoV HKU5 has been sequenced (GenBank: EF065512), as has the complete genome of SARS-CoV, Urbani (GenBank: AY278741), and a mouse-adapted variant (GenBank: DQ497008).

NR-48814 is a synthetic chimeric recombinant coronavirus based on a consensus bat SARS-like coronavirus (SCoV) sequence. The region of the bat SCoV genome encoding the spike (S) glycoprotein ectodomain was replaced with the corresponding region from the SARS-CoV, Urbani genome. A histidine for tyrosine substitution at position 436, previously shown to enhance replication in mice, was also included in the S gene. This virus replicates efficiently in cell culture and in young and aged mice, where the virus targets airway and alveolar epithelial cells.

Each vial contains approximately 1 mL of cell lysate and supernatant from Cercopithecus aethiops kidney epithelial cells (Vero 76, clone E6: ATCC ® CRL-1586™) infected with BtCoV HKU5-SE.

Note: If homogeneity is required for your intended use, please purify prior to initiating work.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Bat SARS-Like Coronavirus, HKU5, Recombinant, Containing the SARS Coronavirus, Urbani Spike Glycoprotein Ectodomain, NR-48814."
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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