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NR-45924  Staphylococcus aureus, SA LinR #12
(Bacteria)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Organism: Staphylococcus aureus
Designations: SA LinR #12
Biosafety Level: 2
Availability Status: In Stock
Store at: -60°C or colder
Contributor: MJ Ferraro
Comments:
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

Staphylococcus aureus (S. aureus), strain SA LinR #12 (also referred to as NRS119) was isolated in 2001 from an 85-year-old male with dialysis-associated peritonitis in Massachusetts, USA.

S. aureus, strain SA LinR #12 is a linezolid-resistant S. aureus (LRSA), methicillin-resistant S. aureus (MRSA) strain. It was deposited as resistant to linezolid and tedizolid; positive for mec (subtype IV); MLST sequence type (ST) 507; eGenomic spa type 7, eGenomic spa repeats YHGCMBQBLO; Ridom spa type t064. S. aureus, strain SA LinR #12 was co-isolated with SA LinR #13 (NRS120) and SA LinR #14 (NRS121) from the first clinically reported case of a MRSA infection that demonstrated resistance to linezolid. Based on pulsed-field gel electrophoresis, SA LinR #12 and SA LinR #13 are identical and SA LinR #14 is closely related to both. While each strain has a different antibiogram, all three are resistant to linezolid due to a G2576T mutation in domain V in one or more 23S rRNA genes (Escherichia coli numbering).

Each vial contains approximately 0.5 mL of bacterial culture in Tryptic Soy broth supplemented with 10% glycerol.

Note: If homogeneity is required for your intended use, please purify prior to initiating work.
Citations: Acknowledgment for publications should read "The following reagent was provided by the Network on Antimicrobial Resistance in Staphylococcus aureus (NARSA) for distribution by BEI Resources, NIAID, NIH: Staphylococcus aureus, Strain SA LinR #12, NR-45924."
Additional Information: NARSA NRS119
Publications Citing
this Reagent:
Silva-Del Toro, S. L., K. E. Greenwood-Quaintance, and R. Patel. "In vitro Activity of Tedizolid Against Linezolid-Resistant Staphylococci and Enterococci." Diagn.Microbiol. Infect. Dis. S0732-8893 (2016): 30009-8. PubMed: 26971179.
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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