TARGET Research Results
Details
DescriptionProbable polyketide synthase pks12
Accession numberRv2048c
Gene namepks12
Gene length12456
Protein length4151
Coordinates2294531..2306986
Orientation-
Molecular mass431580.06
Isoelectric point4.86

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU2048c-7552[no data]
JHU2048c-2248[no data]
JHU2048c-4625[no data]
JHU2048c-6631[no data]
 

CDC1551 Homolog
ORFMT2108
Essentiality Prediction
Sassetti et al, 2003*[no data]

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU2048c-7552MT2108Rv2048c755212456no (will be available later)
JHU2048c-2248MT2108Rv2048c224812456yes
JHU2048c-4625MT2108Rv2048c462512456no (will be available later)
JHU2048c-6631MT2108Rv2048c663112456no (will be available later)
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]