|
Mutant
ID
|
Gene size |
POI |
Gene description |
MT# |
Rv# |
Phenotype |
Essential? |
| H14 |
1271 |
210 |
PPE family protein
(PPE)
|
1850 |
1801 |
Not-Attenuated |
Not-Essential |
| H15 |
1973 |
838 |
cation transporting ATPase, E1-E2 family ctpD |
1515 |
1469 |
Not-Attenuated |
Not-Essential |
| H18 |
965 |
746 |
cyclopropane-fatty-acyl-phospholipid synthase 2 (cmaA2)
|
524 |
503 |
Not-Attenuated |
Not-Essential |
| H22 |
1676 |
60 |
PE_PGRS |
2036 |
1983 |
Not-Attenuated |
Not-Essential |
| H28 |
2381 |
322 |
GTP pyrophosphokinase (relA) |
2660 |
2583 |
Attenuated |
Essential
|
|
| H85 |
449 |
319 |
DNA binding protein, putative |
2005 |
1956 |
Not-Attenuated |
Not-Essential |
| H106 |
899 |
632 |
HP |
1551 |
1502 |
Not-Attenuated |
Not-Essential |
| H125 |
611 |
418 |
IS1537, resolvase |
3936 |
3828 |
Not-Attenuated |
Not-Essential |
| H129 |
860 |
62 |
HP |
3068 |
2990 |
Not-Attenuated |
Not-Essential |
| H131 |
941 |
126 |
conserved HP |
154 |
146 |
Not-Attenuated |
Not-Essential |
| H132 |
4541 |
631 |
ATP-dependent helicase, putative (lhr) |
3395 |
3296 |
Not-Attenuated |
Not-Essential |
| H134 |
1196 |
17 |
conserved HP |
115 |
106 |
Not-Attenuated |
Not-Essential |
| H136 |
542 |
76 |
HP |
364 |
349 |
Not-Attenuated |
Not-Essential |
| H140 |
917 |
30 |
RNA pseudouridylate synthase family |
3399 |
3300 |
Not-Attenuated |
Not-Essential |
| H143 |
1742 |
74 |
acyl-CoA synthase, FadD28 |
3011 |
2941 |
Not-Attenuated |
Not-Essential |
| H144 |
2519 |
459 |
Ferredoxin reductase, electron transfer |
1987 |
1937 |
Not-Attenuated |
Not-Essential |
| H145 |
1346 |
1144 |
HP |
3848 |
3740 |
Not-Attenuated |
Not-Essential |
| H151 |
626 |
462 |
MitM-related protein |
344 |
329 |
Not-Attenuated |
Not-Essential |
| H154 |
392 |
253 |
Conserved HP |
3472 |
3364 |
Not-Attenuated |
Not-Essential |
| H157 |
2099 |
279 |
Conserved HP |
2794 |
2721 |
Not-Attenuated |
Not-Essential |
| H159 |
641 |
169 |
HP |
3503 |
3395 |
Not-Attenuated |
Not-Essential |
| H160 |
1526 |
476 |
Phospholipase C (plcC) |
2414 |
2349 |
Not-Attenuated |
Not-Essential |
| H162 |
974 |
240 |
Conserved HP |
2787 |
2714 |
Not-Attenuated |
Not-Essential |
| H163 |
632 |
336 |
transcriptional regulator, TetR family |
315 |
302 |
Not-Attenuated |
Not-Essential |
| H166 |
1643 |
76 |
Phosphoglucomutase (pgmA) |
3153 |
3068 |
Not-Attenuated |
Not-Essential |
| H168 |
1940 |
859 |
FAD flavoprotein oxidase |
262 |
248 |
Not-Attenuated |
Not-Essential |
| H169 |
524 |
85 |
Cobinamide/cobinamide phosphate guanylyltransferase (cobU)
|
267 |
254 |
Not-Attenuated |
Not-Essential |
| H170 |
617 |
65 |
Phosphatidylethanolamine binding protein (lppC) |
1962 |
1911 |
Not-Attenuated |
Not-Essential |
| H173 |
1076 |
829 |
HP |
953 |
926 |
Not-Attenuated |
Not-Essential |
| H174 |
977 |
56 |
Conserved HP |
917 |
893 |
Not-Attenuated |
Not-Essential |
| H178 |
461 |
129 |
HP (b/w Rv1737/1738) |
1780 |
1738 |
Not-Attenuated |
Not-Essential |
| H179 |
2271 |
1895 |
arylsulfatase (atsA) |
738 |
711 |
Not-Attenuated |
Not-Essential |
| H180 |
1547 |
321 |
virulence factor
mce protein
|
183 |
174 |
Not-Attenuated |
Not-Essential |
| H181 |
1217 |
682 |
penicillin binding protein |
3433 |
3330 |
Not-Attenuated |
Not-Essential |
| H185 |
1367 |
1072 |
Conserved HP |
1628 |
1592 |
Not-Attenuated |
Not-Essential |
| H187 |
716 |
310 |
Conserved HP |
77 |
71 |
Not-Attenuated |
Not-Essential |
| H189 |
1349 |
103 |
sugar transporter family protein (kgtP) |
3580 |
3476 |
Not-Attenuated |
Not-Essential |
| H191 |
857 |
624 |
HP |
3569 |
3463 |
Not-Attenuated |
Not-Essential |
| H192 |
710 |
399 |
lipoprotein, putative (lpqD) |
3497 |
3390 |
Not-Attenuated |
Not-Essential |
| H197 |
395 |
111 |
Conservative HP |
2829 |
2759 |
Not-Attenuated |
Not-Essential |
| H198 |
1688 |
103 |
AMP-binding family protein (fadD34) |
40 |
35 |
Not-Attenuated |
Not-Essential |
| H205 |
1982 |
282 |
Conserved HP |
2410 |
2345 |
Not-Attenuated |
Not-Essential |
| H206 |
1277 |
1116 |
Conservative HP |
3806 |
3703 |
Not-Attenuated |
Not-Essential |
| H215 |
410 |
125 |
protozoan/cianobacterial globin family protein (glbN) |
1594 |
1542 |
Not-Attenuated |
Not-Essential |
| H224 |
3725 |
1738 |
ABC transporter, ATP-binding protein (HP) |
204 |
194 |
Not-Attenuated |
Not-Essential |
| H234 |
1238 |
77 |
Degt/DnrJ/EryC1 family protein (HP) |
3510 |
3402 |
Not-Attenuated |
Not-Essential |
| H245 |
3227 |
1514 |
HP |
3583 |
3479 |
Not-Attenuated |
Not-Essential |
| H250 |
1811 |
1063 |
HP |
1099 |
1069 |
Not-Attenuated |
Not-Essential |
| H251 |
668 |
56 |
HNH endonuclease
family protein
|
2545 |
2469 |
Not-Attenuated |
Not-Essential |
| H252 |
455 |
226 |
HP |
2315 |
2254 |
Not-Attenuated |
Not-Essential |
| H253 |
977 |
598 |
Conserved HP |
2483 |
2410 |
Not-Attenuated |
Not-Essential |
| H254 |
743 |
586 |
serine exterase, cutinase family |
3557 |
3451 |
Not-Attenuated |
Not-Essential |
| H262 |
500 |
350 |
HP |
3838 |
3733 |
Not-Attenuated |
Not-Essential |
| H264 |
774 |
218 |
Conserved HP |
1979 |
1927 |
Not-Attenuated |
Not-Essential |
| H266 |
1007 |
172 |
Quinone oxidoreductase, putative (qor) |
1501 |
1454 |
Not-Attenuated |
Not-Essential |
| H267 |
1145 |
877 |
SPFH domain/Band 7 family protein |
1533.2 |
1488 |
Not-Attenuated |
Not-Essential |
| H269 |
3479 |
896 |
transcriptional regulator, LuxR family |
1402 |
1358 |
Not-Attenuated |
Not-Essential |
| H271 |
1058 |
727 |
HP |
2785 |
2712 |
Not-Attenuated |
Not-Essential |
| H272 |
1421 |
1123 |
amidase family protein (amiC) |
2956 |
2888 |
Not-Attenuated |
Not-Essential |
| H274 |
1697 |
1108 |
HP |
1671 |
1635 |
Moderately-attenauated |
Essential |
|
| H278 |
4196 |
794 |
glycosyl hydrolase |
676 |
648 |
Not-Attenuated |
Not-Essential |
| H279 |
722 |
312 |
proline-rich antigen (pra) |
1109 |
1078 |
Not-Attenuated |
Not-Essential |
| H281 |
1214 |
867 |
virulence factor (mce2) |
618 |
589 |
Not-Attenuated |
Not-Essential |
| H282 |
1166 |
531 |
HP |
2329 |
2267 |
Not-Attenuated |
Not-Essential |
| H284 |
11355 |
7007 |
PPE |
3458 |
3350 |
Not-Attenuated |
Not-Essential |
| H286 |
431 |
153 |
HP |
1861 |
1813 |
Not-Attenuated |
Not-Essential |
| H287 |
962 |
64 |
D-amino acid oxidase |
1956 |
1905 |
Not-Attenuated |
Not-Essential |
| H288 |
419 |
300 |
HP |
1765 |
1724 |
Not-Attenuated |
Not-Essential |
| H289 |
752 |
564 |
Conserved HP |
2749 |
2675 |
Not-Attenuated |
Not-Essential |
| H290 |
1721 |
273 |
GAF family protein |
2086 |
2027 |
Not-Attenuated |
Not-Essential |
| H292 |
476 |
239 |
HP |
2801.1 |
2730 |
Moderately-attenauated |
Essential |
|
| H293 |
1193 |
921 |
membrane protein, mmpL family (mmpL6) |
1608 |
1557 |
Not-Attenuated |
Not-Essential |
| H295 |
1213 |
415 |
cysteine synthase, putative (cysM3) |
871 |
848 |
Not-Attenuated |
Not-Essential |
| H296 |
395 |
112 |
Conserved HP |
652 |
624 |
Not-Attenuated |
Not-Essential |
| H297 |
1811 |
43 |
Ser/Thr protein kinase (pknI) |
2982 |
2914 |
Not-Attenuated |
Not-Essential |
| H298 |
374 |
235 |
Conserved HP |
1172 |
1139 |
Not-Attenuated |
Not-Essential |
| H300 |
1094 |
66 |
Type I restriction system specificity protein |
2831 |
2761 |
Not-Attenuated |
Not-Essential |
| H302 |
626 |
427 |
Transcriptional regulator, MarR family |
48 |
42 |
Not-Attenuated |
Not-Essential |
| H306 |
992 |
36 |
ABC transporter, ATP binding protein |
79 |
73 |
Not-Attenuated |
Not-Essential |
| H307 |
974 |
748 |
Conserved HP |
2780 |
2707 |
Not-Attenuated |
Not-Essential |
| H308 |
218 |
154 |
HP (b/w Rv1139/1140) |
1172.1 |
1139 |
Not-Attenuated |
Not-Essential |
| H310 |
545 |
123 |
HP |
787 |
762 |
Not-Attenuated |
Not-Essential |
| H320 |
927 |
387 |
IS Mt 1 transposase (HP) |
1184 |
1147 |
Not-Attenuated |
Not-Essential |
| H329 |
1799 |
488 |
HP |
1556 |
1508 |
Not-Attenuated |
Not-Essential |
| H331 |
1340 |
1093 |
glutamine synthase (glnA2) |
2280 |
2222 |
Not-Attenuated |
Not-Essential |
| H343 |
1100 |
787 |
Conserved HP |
202 |
192 |
Not-Attenuated |
Not-Essential |
| H349 |
239 |
50 |
Conserved HP |
1625 |
1590 |
Not-Attenuated |
Not-Essential |
| H356 |
4464 |
566 |
polyketide synthase (ppsE) |
3005 |
2935 |
Not-Attenuated |
Not-Essential |
| H361 |
3341 |
919 |
Transcriptional
regulator, LuxR family (HP)
|
2563 |
2488 |
Not-Attenuated |
Not-Essential |
| H365 |
341 |
67 |
Conserved HP |
2883 |
2816 |
Not-Attenuated |
Not-Essential |
| H370 |
293 |
123 |
HP |
2407 |
2342 |
Not-Attenuated |
Not-Essential |
| H376 |
1142 |
894 |
Conserved HP |
2239 |
2184 |
Not-Attenuated |
Not-Essential |
| H383 |
438 |
339 |
transcriptional regulator, MerR family |
3438 |
3334 |
Not-Attenuated |
Not-Essential |
| H388 |
3197 |
2589 |
Drug transporter |
3337 |
3239 |
Not-Attenuated |
Not-Essential |
| H389 |
1391 |
715 |
PPE |
105 |
96 |
Not-Attenuated |
Not-Essential |
| H391 |
1691 |
187 |
HP |
3176 |
3091 |
Not-Attenuated |
Not-Essential |
| H392 |
1280 |
400 |
P450 heme-thiolate protein |
1834 |
1785 |
Not-Attenuated |
Not-Essential |
| H394 |
1643 |
63 |
TPP requiring enzyme ilvG (acetoactate synthase) |
1868 |
1820 |
Not-Attenuated |
Not-Essential |
| H407 |
431 |
333 |
HP |
2674 |
2599 |
Not-Attenuated |
Not-Essential |
| H408 |
1616 |
586 |
HP |
1223 |
1186 |
Not-Attenuated |
Not-Essential |
| H410 |
902 |
39 |
1,3,4,6-tetrachloro-1,4-cyclohexadiene hydrolase (linB) |
2656 |
2579 |
Not-Attenuated |
Not-Essential |
| H411 |
1058 |
244 |
transcriptional regulator, AraC family (virS) |
3167 |
3082 |
Not-Attenuated |
Not-Essential |
| H415 |
1427 |
426 |
amidase family protein (amiD) |
3485 |
3375 |
Not-Attenuated |
Not-Essential |
| H421 |
1187 |
493 |
fatty acid-CoA racemase (mcr) |
1176 |
1143 |
Not-Attenuated |
Not-Essential |
| H423 |
2585 |
609 |
amino peptidase N (pepD) |
2542 |
2467 |
Not-Attenuated |
Not-Essential |
| H424 |
557 |
260 |
HP |
769 |
743 |
Not-Attenuated |
Not-Essential |
| H426 |
1004 |
326 |
4-hydroxy-2-oxovalerate aldolase (mphE) |
3575 |
3469 |
Not-Attenuated |
Not-Essential |
| H427 |
1160 |
737 |
PPE family protein (PPE) |
1856.1 |
1808 |
Not-Attenuated |
Not-Essential |
| H432 |
1160 |
527 |
MutT/nudix family protein |
3293 |
3199 |
Not-Attenuated |
Not-Essential |
| H433 |
809 |
586 |
conserved HP |
462 |
446 |
Not-Attenuated |
Not-Essential |
| H437 |
413 |
39 |
HP |
2992 |
2923 |
Not-Attenuated |
Not-Essential |
| H438 |
1190 |
144 |
oxidoreductase, pyridine nucleotide-disulphide family |
1860 |
1812 |
Not-Attenuated |
Not-Essential |
| H439 |
1115 |
490 |
HP |
1078 |
1048 |
Not-Attenuated |
Not-Essential |
| H445 |
1397 |
950 |
sulfatase family protein (atsG) |
310 |
296 |
Moderately-attenuated |
Essential |
|
| H446 |
2906 |
2203 |
membrane protein, mmpL family (mmpL2) |
528 |
507 |
Not-Attenuated |
Not-Essential |
| H447 |
776 |
395 |
HP |
3947 |
3839 |
Not-Attenuated |
Not-Essential |
| H449 |
965 |
295 |
diacylglycerol kinase catalytic domain-containing protein |
3314 |
3218 |
Not-Attenuated |
Not-Essential |
| H450 |
254 |
26 |
conserved HP |
3292 |
3198 |
Not-Attenuated |
Not-Essential |
| H451 |
1031 |
747 |
N5, N10 methylene tetrahydromethaopterin reductase related protein
|
3621 |
3520 |
Not-Attenuated |
Not-Essential |
| H456 |
1157 |
507 |
acetate kinase (ackA) |
422 |
409 |
Not-Attenuated |
Not-Essential |
| H457 |
1355 |
1110 |
conserved HP |
501 |
483 |
Not-Attenuated |
Not-Essential |
| H471 |
968 |
48 |
Quinone oxidoreductase |
157 |
149 |
Not-Attenuated |
Not-Essential |
| H472 |
1409 |
1181 |
HP |
4002 |
3887 |
Not-Attenuated |
Not-Essential |
| H474 |
992 |
251 |
ABC transporter |
79 |
73 |
Not-Attenuated |
Not-Essential |
| H476 |
1565 |
274 |
Conserved HP |
23 |
20 |
Not-Attenuated |
Not-Essential |
| H478 |
3041 |
2737 |
PPE family protein |
1969 |
1918 |
Not-Attenuated |
Not-Essential |
| H482 |
1283 |
340 |
cyclopropane-fattyacyl-phospholipid synthase |
3823 |
3720 |
Not-Attenuated |
Not-Essential |
| H484 |
1232 |
968 |
acyl-CoA dehydrogenase (fadE21) |
2859 |
2789 |
Not-Attenuated |
Not-Essential |
| H485 |
2432 |
1504 |
Penicillin binding protein 1 (ponA) |
3784 |
3682 |
Not-Attenuated |
Not-Essential |
| H487 |
419 |
46 |
HP |
2832 |
2762 |
Not-Attenuated |
Not-Essential |
| H490 |
734 |
96 |
conserved HP |
190 |
181 |
Not-Attenuated |
Not-Essential |
| H491 |
7562 |
5881 |
peptide synthase (nrp) |
110 |
101 |
Attenuated |
Essential |
|
| H493 |
144 |
15 |
HP |
2527.1 |
2452 |
Not-Attenuated |
Not-Essential |
| H494 |
2339 |
3 |
formate dehydrogenase, alpha-subunit (fdhF) |
2968 |
2900 |
Not-Attenuated |
Not-Essential |
| H495 |
1364 |
400 |
HP |
3839 |
3734 |
Not-Attenuated |
Not-Essential |
| H496 |
7562 |
364 |
peptide synthase (nrp) |
110 |
101 |
Attenuated |
Essential |
|
| H498 |
1715 |
1477 |
potassium-transporting ATPase, A subunit (kdpA) |
1058 |
1029 |
Not-Attenuated |
Not-Essential |
| H500 |
695 |
369 |
enoyl-CoA hydratase/isomerase family protein (echA3) |
660 |
632 |
Not-Attenuated |
Not-Essential |
| H501 |
6301 |
3939 |
polyketide synthase (pks5) |
1578 |
1527 |
Not-Attenuated |
Not-Essential |
| H502 |
1175 |
298 |
HP |
1025 |
996 |
Not-Attenuated |
Not-Essential |
| H503 |
2315 |
322 |
ATP dependent RNA helicase, DEAD/DEAH box family |
3751 |
3649 |
Not-Attenuated |
Not-Essential |
| H508 |
1112 |
897 |
phosphate ABC transporter, phosphate binding protein (pstS)
|
959 |
932 |
Not-Attenuated |
Not-Essential |
| H510 |
2045 |
1128 |
sensory box protein/ anti-anti-sigma factor (rsbU) |
1410 |
1364 |
Not-Attenuated |
Not-Essential |
| H511 |
1046 |
69 |
GDP-D-mannose dehydratase (gmdA) |
1561 |
1511 |
Not-Attenuated |
Not-Essential |
| H513 |
401 |
210 |
HP |
71 |
65 |
Not-Attenuated |
Not-Essential |
| H515 |
2633 |
1329 |
conserved HP |
612 |
584 |
Not-Attenuated |
Not-Essential |
| H521 |
9500 |
6665 |
PPE |
3453 |
3347 |
Not-Attenuated |
Not-Essential |
| H523 |
1487 |
1116 |
monoxygenase flavin binding family |
3168 |
3083 |
Not-Attenuated |
Not-Essential |
| H533 |
1628 |
789 |
HP |
3885 |
3776 |
Not-Attenuated |
Not-Essential |
| H542 |
1598 |
836 |
cpsY protein |
826 |
806 |
Not-Attenuated |
Not-Essential |
| H587 |
1832 |
331 |
CbxX/CfgX -related protein |
1847 |
1798 |
Attenuated |
Essential |
|
| H601 |
1481 |
11 |
malate: quinone oxireductase |
2918 |
2852 |
Not-Attenuated |
Not-Essential |
| H604 |
2054 |
1185 |
LytR/CpsA/Psr family protein |
844 |
822 |
Not-Attenuated |
Not-Essential |
| H614 |
356 |
55 |
HP |
1775 |
|
Not-Attenuated |
Not-Essential |
| H616 |
389 |
221 |
HP |
3462 |
3354 |
Not-Attenuated |
Not-Essential |
| H617 |
842 |
316 |
transcriptional regulator, TetR family |
152 |
144 |
Not-Attenuated |
Not-Essential |
| H703 |
1160 |
300 |
acyl CoA dehydrogenase, fad E14 |
1388 |
1346 |
Not-Attenuated |
Not-Essential |
| H705 |
2720 |
192 |
ATP-dependent DNA helicase, DAD/DEAHBox |
2153 |
2092 |
Not-Attenuated |
Not-Essential |
| H726 |
470 |
66 |
HP |
1548 |
1499 |
Not-Attenuated |
Not-Essential |
| H728 |
1322 |
253 |
amino acid permease |
2055 |
1999 |
Not-Attenuated |
Not-Essential |
| H731 |
866 |
234 |
PEG1/MEST protein |
1882 |
1834 |
Not-Attenuated |
Not-Essential |
| H735 |
284 |
192 |
Conserved HP : multiple hits |
1236 |
1198 |
Not-Attenuated |
Not-Essential |
| H741 |
695 |
291 |
HP |
3306 |
3210 |
Attenuated |
Essential |
|
| H742 |
293 |
94 |
HP |
3269 |
|
Not-Attenuated |
Not-Essential |
| H743 |
1457 |
276 |
sensor histidine kinase(phoR) |
783 |
758 |
Moderately-attenauated |
Essential |
|
| H744 |
1226 |
832 |
conserved HP
|
490 |
473 |
Not-Attenuated |
Not-Essential |
| H745 |
1367 |
317 |
CBS domain protein |
1890 |
1842 |
Not-Attenuated |
Not-Essential |
| H747 |
2615 |
2303 |
sensor histidine kinase (kpdD) |
1057 |
1028 |
Moderately-attenauated |
Essential |
|
| H751 |
935 |
249 |
RNA pol. Sigma factor (sigC) (insertion is upstream of Rv2069)
|
2129 |
2069 |
Not-Attenuated |
Not-Essential |
| H758 |
443 |
233 |
HP |
2978 |
2910 |
Not-Attenuated |
Not-Essential |
| H765 |
2837 |
2406 |
Conserved membrane protein, mmpL family (deleted in H37Rv)
|
1802 |
|
Not-Attenuated |
Not-Essential |
| H768 |
347 |
95 |
HP |
3276 |
3188 |
Not-Attenuated |
Not-Essential |
| H770 |
623 |
45 |
Conserved HP |
799 |
775 |
Not-Attenuated |
Not-Essential |
| H774 |
1793 |
177 |
very-long-chain acyl-CoA synthetase (fadD6) |
1244 |
1206 |
Not-Attenuated |
Not-Essential |
| H775 |
683 |
144 |
immunogenic protein MPB64/MPT64 precursor |
3121 |
3036 |
Not-Attenuated |
Not-Essential |
| H776 |
1016 |
224 |
oxidorectase, short chain, dehydrogenase/reductase family
|
455 |
439 |
Not-Attenuated |
Not-Essential |
| H778 |
836 |
448 |
Conserved HP |
1102 |
1072 |
Not-Attenuated |
Not-Essential |
| H779 |
1217 |
166 |
PPE |
1836 |
1787 |
Not-Attenuated |
Not-Essential |
| H784 |
1043 |
671 |
HP |
816 |
791 |
Not-Attenuated |
Not-Essential |
| H798 |
1112 |
979 |
RNA pol. Sigma factor (sigG) |
191 |
182 |
Not-Attenuated |
Not-Essential |
| H815 |
623 |
470 |
carbonic anhydrase |
3694 |
3588 |
Not-Attenuated |
Not-Essential |
| H826 |
731 |
251 |
PPE |
2167 |
2108 |
Not-Attenuated |
Not-Essential |
| H838 |
1217 |
138 |
P450 heme-thiolate protein |
1295 |
1256 |
Not-Attenuated |
Not-Essential |
| H844 |
710 |
280 |
Conserved HP |
2888 |
2821 |
Attenuated |
Essential |
|
| H846 |
1736 |
1495 |
Conserved HP (choD) |
3517 |
3409 |
Not-Attenuated |
Not-Essential |
| H851 |
2567 |
1595 |
Conserved HP |
1015 |
987 |
Not-Attenuated |
Not-Essential |
| H855 |
1040 |
409 |
PPE |
1205 |
1168 |
Not-Attenuated |
Not-Essential |
| H859 |
1529 |
303 |
HP |
3801 |
3698 |
Not-Attenuated |
Not-Essential |
| H872 |
437 |
236 |
HP |
3369 |
3269 |
Not-Attenuated |
Not-Essential |
| H874 |
2021 |
967 |
Prolyl oligopeptidase family protein |
473 |
457 |
Not-Attenuated |
Not-Essential |
| H881 |
578 |
281 |
HP |
3595 |
3491 |
Not-Attenuated |
Not-Essential |
| H887 |
1226 |
390 |
sugar transporter family protein (nanT) |
1953 |
1902 |
Not-Attenuated |
Not-Essential |
| H888 |
1349 |
634 |
HP |
260 |
246 |
Not-Attenuated |
Not-Essential |
| H892 |
863 |
578 |
ABC transporter |
3126 |
3041 |
Not-Attenuated |
Not-Essential |
| H893 |
1121 |
171 |
glycosyl transferase |
1566 |
1516 |
Not-Attenuated |
Not-Essential |
| H900 |
1688 |
637 |
HP |
2866 |
2797 |
Not-Attenuated |
Not-Essential |
| H901 |
1175 |
827 |
PPE |
3209 |
3125 |
Not-Attenuated |
Not-Essential |
| H902 |
293 |
147 |
HP |
2593.1 |
2517 |
Not-Attenuated |
Not-Essential |
| H905 |
656 |
257 |
conserved HP |
449 |
434 |
Not-Attenuated |
Not-Essential |
| H906 |
560 |
271 |
HP |
2043 |
1989 |
Not-Attenuated |
Not-Essential |
| G21 |
1703 |
1410 |
adenylate cyclase, putative |
1362 |
1320 |
Not-Attenuated |
Not-Essential |
| G30 |
380 |
211 |
HP |
148 |
140 |
Not-Attenuated |
Not-Essential |
| G40 |
941 |
472 |
HP |
740 |
713 |
Not-Attenuated |
Not-Essential |
| G41 |
953 |
187 |
Methoxy mycolic acid synthase 2 (mmaA2) |
672 |
644 |
Not-Attenuated |
Not-Essential |
| G43 |
1091 |
47 |
HP |
848 |
826 |
Not-Attenuated |
Not-Essential |
| G44 |
1706 |
1 |
Acyl-CoA dehydrogenase (fadE4) |
241 |
231 |
Not-Attenuated |
Not-Essential |
| G46 |
2900 |
560 |
Membrane protein MmpL11 |
212 |
202 |
Not-Attenuated |
Not-Essential |
| G53 |
890 |
541 |
Methoxy mycolic acid synthase 1 (mmaA1) |
673 |
645 |
Not-Attenuated |
Not-Essential |
| G54 |
1511 |
1175 |
Substrate CoA-ligase |
3174 |
3089 |
Not-Attenuated |
Not-Essential |
| G59 |
1142 |
548 |
Cellulase |
67 |
62 |
Not-Attenuated |
Not-Essential |
| G60 |
1682 |
154 |
Sulfate transporter |
1781 |
1739 |
Not-Attenuated |
Not-Essential |
| G62 |
2099 |
324 |
Conserved HP |
1917 |
1868 |
Not-Attenuated |
Not-Essential |
| G66 |
1595 |
545 |
NADH dehydrogenase I, subunit N (nuoN) |
3246 |
3158 |
Not-Attenuated |
Not-Essential |
| G69 |
1886 |
1613 |
GTP binding elongation factor family protein |
1202 |
1165 |
Not-Attenuated |
Not-Essential |
| G73 |
794 |
343 |
Ribonuclease HII |
2970 |
2902 |
Not-Attenuated |
Not-Essential |
| G74 |
2087 |
356 |
HP |
2942 |
2875 |
Not-Attenuated |
Not-Essential |
| G77 |
1826 |
510 |
HP |
203 |
193 |
Not-Attenuated |
Not-Essential |
| G79 |
1322 |
95 |
Thiolase |
257 |
243 |
Not-Attenuated |
Not-Essential |
| G80 |
890 |
540 |
Conserved HP, truncation |
2821 |
2751 |
Not-Attenuated |
Not-Essential |
| G100 |
290 |
109 |
Conserved HP |
2420 |
2346 |
Not-Attenuated |
Not-Essential |
| G103 |
671 |
502 |
PPE family protein |
2505 |
2430 |
Not-Attenuated |
Not-Essential |
| G104 |
1073 |
282 |
glycosyl transferase
|
1570 |
1520 |
Not-Attenuated |
Not-Essential |
| G107 |
3440 |
349 |
membrane protein, (mmpL12) |
1573 |
1522 |
Not-Attenuated |
Not-Essential |
| G109 |
1439 |
442 |
mitR protein |
68 |
63 |
Not-Attenuated |
Not-Essential |
| G111 |
1172 |
502 |
Acyl-CoA dehydrogenase (FadE9) |
776 |
752 |
Not-Attenuated |
Not-Essential |
| G112 |
1556 |
1357 |
substrate CoA ligase |
175 |
166 |
Not-Attenuated |
Not-Essential |
| G116 |
416 |
321 |
HP |
2075 |
2019 |
Not-Attenuated |
Not-Essential |
| G118 |
845 |
102 |
Bem 46 protein |
2364 |
2307 |
Not-Attenuated |
Not-Essential |
| G121 |
1115 |
295 |
PPE family protein |
3987 |
3873 |
Not-Attenuated |
Not-Essential |
| G122 |
1268 |
518 |
HP |
4000 |
3885 |
Not-Attenuated |
Not-Essential |
| G126 |
725 |
382 |
Nitrate reductase, gamma subunit |
1201 |
1164 |
Not-Attenuated |
Not-Essential |
| G130 |
383 |
165 |
HP |
641 |
611 |
Not-Attenuated |
Not-Essential |
| G137 |
1676 |
357 |
adenylate cyclase, putative |
1361 |
no Rv |
Not-Attenuated |
Not-Essential |
| G150 |
752 |
411 |
Conserved HP |
2749 |
2675 |
Not-Attenuated |
Not-Essential |
| G159 |
1253 |
59 |
Exonuclease SbcD-related protein |
1314 |
1277 |
Not-Attenuated |
Not-Essential |
| G162 |
1406 |
1002 |
Acyl-CoA dehydrogenase (fadE24) |
3226 |
3139 |
Not-Attenuated |
Not-Essential |
| G171 |
431 |
314 |
HP |
1280 |
1242 |
Not-Attenuated |
Not-Essential |
| G175 |
767 |
545 |
HP |
2051 |
1995 |
Not-Attenuated |
Not-Essential |
| G181 |
794 |
514 |
conserved HP |
50 |
44 |
Not-Attenuated |
Not-Essential |
| G182 |
1919 |
516 |
ABC transporter |
1867 |
1819 |
Not-Attenuated |
Not-Essential |
| G184 |
1772 |
557 |
Succinate
dehydrogenase, flavoprotein subunit
|
3419 |
3318 |
Not-Attenuated |
Not-Essential |
| G189 |
1253 |
444 |
HP |
3258 |
3169 |
Not-Attenuated |
Not-Essential |
| G190 |
1772 |
442 |
Succinate dehydrogenase, flavoprotein subunit (sdhA) |
3419 |
3318 |
Not-Attenuated |
Not-Essential |
| G194 |
1385 |
619 |
P450 heme-thiolate protein |
1439 |
1394 |
Not-Attenuated |
Not-Essential |
| G204 |
1277 |
872 |
putative oxidoreductase |
398 |
385 |
Not-Attenuated |
Not-Essential |
| G205 |
1181 |
1021 |
HP |
2847 |
2777 |
Not-Attenuated |
Not-Essential |
| G209 |
557 |
287 |
conserved HP |
459 |
443 |
Not-Attenuated |
Not-Essential |
| G211 |
869 |
568 |
HP |
54 |
48 |
Not-Attenuated |
Not-Essential |
| G279 |
3278 |
1651 |
transcriptional regulator, LuxR family |
399 |
386 |
Not-Attenuated |
Not-Essential |
| G282 |
170 |
33 |
rubredoxin |
3349 |
3251 |
Not-Attenuated |
Not-Essential |
| G318 |
4619 |
47 |
cation-transporting ATPase E1-E2 family |
440 |
425 |
Not-Attenuated |
Not-Essential |
| G416 |
1346 |
288 |
nicotinate
phosphoribosyltransferase, putative
|
1372 |
1330 |
Not-Attenuated |
Not-Essential |
| G432 |
1010 |
390 |
carboxyl esterase (ligG) |
674 |
646 |
Not-Attenuated |
Not-Essential |
| G441 |
1157 |
4 |
rec F protein
|
3 |
3 |
Not-Attenuated |
Not-Essential |
| G442 |
866 |
347 |
CDP diacylglycerol serine (pssA) |
452 |
436 |
Not-Attenuated |
Not-Essential |
| G444 |
1031 |
166 |
Heat shock gene transcriptional repressor (HrcA) |
2443 |
2374 |
Not-Attenuated |
Not-Essential |
| G463 |
680 |
524 |
HP |
239 |
229 |
Not-Attenuated |
Not-Essential |
| G476 |
2888 |
29 |
membrane protein, mmpL9 |
2402 |
2339 |
Not-Attenuated |
Not-Essential |
| G477 |
821 |
315 |
Conserved HP |
1380 |
1339 |
Not-Attenuated |
Not-Essential |
| G483 |
713 |
506 |
Carboxymethylenebutenolidase, putative (HP) |
2114 |
2054 |
Not-Attenuated |
Not-Essential |
| G493 |
350 |
238 |
HP |
3976 |
3862 |
Not-Attenuated |
Not-Essential |
| G506 |
902 |
67 |
Haloalkane dehalogenase (HP) |
2353 |
2296 |
Not-Attenuated |
Not-Essential |
| G510 |
1970 |
1444 |
HP |
2140 |
2079 |
Not-Attenuated |
Not-Essential |
| G514 |
1811 |
112 |
Long chain fatty acid CoA ligase, putative |
2242 |
2187 |
Not-Attenuated |
Not-Essential |
| G518 |
734 |
310 |
HP |
187 |
178 |
Not-Attenuated |
Not-Essential |
| G519 |
795 |
74 |
HP |
2616 |
2542 |
Not-Attenuated |
Not-Essential |
| G523 |
737 |
27 |
Conserved HP |
3035 |
2959 |
Not-Attenuated |
Not-Essential |
| G526 |
1049 |
542 |
Conserved HP |
78 |
72 |
Not-Attenuated |
Not-Essential |
| G527 |
311 |
38 |
HP |
3545 |
3440 |
Not-Attenuated |
Not-Essential |
| G528 |
191 |
141 |
HP |
2365 |
2307 |
Not-Attenuated |
Not-Essential |
| G531 |
1169 |
393 |
acyl-CoA-dehydrogenase |
3374 |
3274 |
Not-Attenuated |
Not-Essential |
| G532 |
2876 |
1222 |
membrane protein, mmpL1 family |
412 |
402 |
Not-Attenuated |
Not-Essential |
| G534 |
419 |
329 |
Aspartate 1-decarboxylase (panD) |
3706.1 |
3601 |
Attenuated |
Essential |
|
| G536 |
1856 |
1242 |
Penicillin binding protein, putative (HP) |
2933 |
2864 |
Not-Attenuated |
Not-Essential |
| G539 |
842 |
139 |
MaoC family protein (HP) |
255 |
241 |
Not-Attenuated |
Not-Essential |
| G568 |
456 |
204 |
Conserved HP |
2674.1 |
2600 |
Not-Attenuated |
Not-Essential |
| G576 |
284 |
95 |
Conserved HP |
1618 |
1567 |
Moderately-attenauated |
Essential |
|
| G583 |
827 |
359 |
Acyltransferase family protein (HP) |
1471 |
1428 |
Not-Attenuated |
Not-Essential |
| G584 |
452 |
6 |
Ferric uptake regulation protein (furA) |
1960 |
1909 |
Not-Attenuated |
Not-Essential |
| G588 |
641 |
179 |
HP |
2072 |
2016 |
Not-Attenuated |
Not-Essential |
| G589 |
2282 |
869 |
Cell division protein FtsH |
3714 |
3610 |
Not-Attenuated |
Not-Essential |
| G590 |
698 |
345 |
HP |
1306 |
1268 |
Not-Attenuated |
Not-Essential |
| G592 |
656 |
70 |
Succinyl-CoA-3-Ketoacid-Coenzyme A transferase |
2578 |
2503 |
Not-Attenuated |
Not-Essential |
| G598 |
887 |
439 |
RNA pol sigma factor, putative (pvdS) |
3329 |
3232 |
Not-Attenuated |
Not-Essential |
| G611 |
1256 |
920 |
Conserved HP |
3027 |
2953 |
Not-Attenuated |
Not-Essential |
| G625 |
860 |
367 |
Oxidoreductase, short-chain dehydrogenase/reductase family
|
1914 |
1865 |
Not-Attenuated |
Not-Essential |
| G627 |
1280 |
519 |
esterase, putative (lipD) |
1974 |
1923 |
Not-Attenuated |
Not-Essential |
| G628 |
228 |
165 |
SPFH domain/band 7 family protein (b/w Rv1489/14490) |
1535 |
1489 |
Not-Attenuated |
Not-Essential |
| G641 |
1535 |
1257 |
conserved HP
|
3932 |
3824 |
Not-Attenuated |
Not-Essential |
| G643 |
533 |
55 |
RNA pol sigma 70 factor, ECF family(sigL)
|
759 |
735 |
Not-Attenuated |
Not-Essential |
| G645 |
983 |
18 |
esterase (lipF) |
3591 |
3487 |
Not-Attenuated |
Not-Essential |
| G646 |
1676 |
165 |
nitrate reductase, b-subunit (narH) |
1199 |
1162 |
Not-Attenuated |
Not-Essential |
| G659 |
938 |
365 |
HP |
3541 |
3435 |
Not-Attenuated |
Not-Essential |
| G671 |
710 |
358 |
Conserved HP |
2262 |
2206 |
Not-Attenuated |
Not-Essential |
| G673 |
1166 |
384 |
oxidoreductase, putative |
346 |
331 |
Not-Attenuated |
Not-Essential |
| G675 |
2414 |
837 |
Conserved HP |
1915 |
1866 |
Not-Attenuated |
Not-Essential |
| G676 |
1124 |
651 |
conserved hypothetical transmembrane protein |
3731 |
3629 |
Not-Attenuated |
Not-Essential |
| G678 |
725 |
443 |
N-acetylmuramyl-L-alanine amidase - related |
3820 |
3717 |
Not-Attenuated |
Not-Essential |
| G682 |
1310 |
751 |
HP |
3166 |
3081 |
Not-Attenuated |
Not-Essential |
| G686 |
647 |
284 |
ribosomal L25 family protein (rplY) |
1043 |
1015 |
Not-Attenuated |
Not-Essential |
| G690 |
509 |
273 |
HP |
281 |
268 |
Not-Attenuated |
Not-Essential |
| G697 |
1208 |
581 |
P450-heme thiolate protein |
790 |
766 |
Not-Attenuated |
Not-Essential |
| G698 |
932 |
134 |
hydrolase, alpha/beta hydrolase fold family |
3411 |
3312 |
Not-Attenuated |
Not-Essential |
| G704 |
230 |
177 |
HP |
974 |
947 |
Not-Attenuated |
Not-Essential |
| G708 |
425 |
98 |
HP |
1484 |
1439 |
Not-Attenuated |
Not-Essential |
| G716 |
1232 |
465 |
PPE |
3844 |
3739 |
Not-Attenuated |
Not-Essential |
| G720 |
1064 |
276 |
non-specific lifpid transfer protein, possible (HP) |
3622.1 |
3522 |
Not-Attenuated |
Not-Essential |
| G722 |
947 |
333 |
methoxy mycolic acid synthase 4(mmaA4)
|
670 |
642 |
Not-Attenuated |
Not-Essential |
| G723 |
1244 |
745 |
L-lactate dehydrogenase
(lldD2)
|
1921 |
1872 |
Attenuated |
Essential |
|
| G724 |
2282 |
1147 |
PPE family protein (PPE) |
1599 |
1548 |
Not-Attenuated |
Not-Essential |
| G726 |
1655 |
590 |
conserved HP |
2484 |
2411 |
Not-Attenuated |
Not-Essential |
| G727 |
2186 |
419 |
cell division control protein, putative |
451 |
435 |
Not-Attenuated |
Not-Essential |
| G728 |
1871 |
418 |
HP |
2289 |
2230 |
Not-Attenuated |
Not-Essential |
| G732 |
2300 |
662 |
molybdopterin oxidoreductase(bisC)
|
1487 |
1442 |
Not-Attenuated |
Not-Essential |
| G745 |
1073 |
459 |
virulence factor mce family protein |
3601 |
3497 |
Moderately-attenauated |
Essential |
|
| G747 |
1214 |
724 |
glucose-1-phosphate adenylyltransferase (glgC) |
1251 |
1213 |
Not-Attenuated |
Not-Essential |
| G757 |
1913 |
732 |
DNA pol III, epsilon subunit, putative |
2247 |
2191 |
Not-Attenuated |
Not-Essential |
| G763 |
1160 |
13 |
Thiolase (fadA6) |
3660 |
3556 |
Not-Attenuated |
Not-Essential |
| G769 |
1424 |
349 |
conserved HP |
3173 |
3088 |
Not-Attenuated |
Not-Essential |
| G773 |
815 |
427 |
immunogenic protein MPB64/MPT64 (mpt64) |
2032 |
1980 |
Not-Attenuated |
Not-Essential |
| G779 |
470 |
179 |
HP |
1922 |
1873 |
Not-Attenuated |
Not-Essential |
| G785 |
830 |
214 |
DNA binding response regulator TrcR |
1062 |
1033 |
Not-Attenuated |
Not-Essential |
| G787 |
1703 |
508 |
HP |
1035 |
1006 |
Not-Attenuated |
Not-Essential |
| G788 |
4862 |
1257 |
Polyketide synthase (pks1) |
3018 |
2946 |
Not-Attenuated |
Not-Essential |
| G789 |
956 |
172 |
HP |
1105 |
1075 |
Not-Attenuated |
Not-Essential |
| G790 |
671 |
247 |
HP |
338 |
323 |
Not-Attenuated |
Not-Essential |
| G791 |
1007 |
755 |
3-oxoacyl-(acyl-carrier-protein) synthase III (fabH) |
557 |
533 |
Not-Attenuated |
Not-Essential |
| G792 |
9560 |
2397 |
PPE family protein (PPE) |
318 |
304 |
Not-Attenuated |
Not-Essential |
| G800 |
785 |
68 |
HP |
2300 |
2240 |
Not-Attenuated |
Not-Essential |
| G802 |
9827 |
3661 |
PPE family protein (PPE) |
370 |
355 |
Not-Attenuated |
Not-Essential |
| G804 |
2360 |
533 |
conserved HP |
3509 |
3401 |
Not-Attenuated |
Not-Essential |
| G805 |
4475 |
1903 |
PPE family protein (PPE) |
1968 |
1917 |
Not-Attenuated |
Not-Essential |
| G811 |
524 |
139 |
siderosphore binding protein, putative |
3625 |
3525 |
Not-Attenuated |
Not-Essential |
| G813 |
398 |
72 |
HP |
3964 |
3849 |
Not-Attenuated |
Not-Essential |
| G815 |
3269 |
68 |
membrane protein, mmpL family (mmpL8) |
3931 |
3823 |
Attenuated |
Essential |
|
| G819 |
1229 |
484 |
IS 1553 transposase |
3742 |
3640 |
Not-Attenuated |
Not-Essential |
| G824 |
1517 |
1176 |
HP |
3584 |
3480 |
Not-Attenuated |
Not-Essential |
| G827 |
1721 |
347 |
ATPase, AAA family |
3981 |
3868 |
Moderately-attenauated |
Essential |
|
| G828 |
1250 |
207 |
alkane-1-monooxygenase |
3350 |
3252 |
Not-Attenuated |
Not-Essential |
| G829 |
923 |
593 |
conserved HP |
1400 |
1357 |
Not-Attenuated |
Not-Essential |
| G832 |
383 |
114 |
HP |
1810 |
1761 |
Not-Attenuated |
Not-Essential |
| G840 |
902 |
193 |
hydrolase, alpha/beta hydrolase fold family (HP) |
3266 |
3177 |
Not-Attenuated |
Not-Essential |
| G846 |
608 |
187 |
IS1536, resolvase
(HP)
|
633 |
605 |
Not-Attenuated |
Not-Essential |
| G847 |
1049 |
326 |
biotin synthase (bioB) |
1624 |
1589 |
Attenuated |
Essential |
|
| G849 |
1811 |
883 |
sulfatase family protein (atsF) |
3162 |
3077 |
Not-Attenuated |
Not-Essential |
| G850 |
1349 |
72 |
lysine-epsilon aminotransferase (lat) |
3389 |
3290 |
Not-Attenuated |
Not-Essential |
| G851 |
1076 |
76 |
DNA ligase, putative (ligC) |
3836 |
3731 |
Not-Attenuated |
Not-Essential |
| G856 |
1895 |
1328 |
ABC transporter ATP-binding protein (HP) |
1310 |
1272 |
Not-Attenuated |
Not-Essential |
| G857 |
284 |
12 |
Conserved HP |
2411 |
2346 |
Not-Attenuated |
Not-Essential |
| G862 |
527 |
225 |
transcriptional regulatory, Mar family (HP) |
1448 |
1404 |
Not-Attenuated |
Not-Essential |
| H915 |
977 |
484 |
HP |
2637 |
2560 |
Not-Attenuated |
Not-Essential |
| H916 |
1751 |
1020 |
acyl-CoA synthase (fadD25) |
1572 |
1521 |
Not-Attenuated |
Not-Essential |
| H917 |
1525 |
1019 |
HP |
4001 |
3886 |
Not-Attenuated |
Not-Essential |
| H918 |
1586 |
912 |
PE family protein |
1474 |
1430 |
Not-Attenuated |
Not-Essential |
| H919 |
599 |
24 |
chorismate
mutase related protein
|
1933 |
1885 |
Not-Attenuated |
Not-Essential |
| H920 |
236 |
11 |
HP |
2080.1 |
xxx |
Not-Attenuated |
Not-Essential |
| H922 |
626 |
84 |
HP |
1082 |
xxx |
Not-Attenuated |
Not-Essential |
| H925 |
662 |
418 |
HP |
1407 |
1362 |
Not-Attenuated |
Not-Essential |
| H929 |
191 |
114 |
HP |
1520 |
xxx |
Not-Attenuated |
Not-Essential |
| H936 |
1571 |
184 |
spermidine synthase (speE) |
2675 |
2601 |
Not-Attenuated |
Not-Essential |
| H954 |
728 |
36 |
Conserved HP |
755 |
730 |
Not-Attenuated |
Not-Essential |
| J11 |
1562 |
588 |
Phospholipase C (plcA?) |
2416 |
2351 |
Not-Attenuated |
Not-Essential |
| J16 |
2639 |
983 |
PE-PGRS protein |
855 |
834 |
Not-Attenuated |
Not-Essential |
| J17 |
644 |
153 |
transcriptional regulator, TetR family |
167 |
158 |
Not-Attenuated |
Not-Essential |
| J19 |
1286 |
1128 |
oxidoreductase, FAD binding |
1821 |
1771 |
Not-Attenuated |
Not-Essential |
| J21 |
842 |
202 |
HP |
2093 |
2033 |
Not-Attenuated |
Not-Essential |
| J23 |
1691 |
125 |
ATP-dependent RNA helicase (deaD) |
1292 |
1253 |
Not-Attenuated |
Not-Essential |
| J24 |
2344 |
1639 |
HP |
1179.1 |
1146 |
Not-Attenuated |
Not-Essential |
| J26 |
362 |
57 |
HP |
766 |
740 |
Not-Attenuated |
Not-Essential |
| J29 |
1595 |
337 |
HP |
1809 |
1760 |
Not-Attenuated |
Not-Essential |
| J30 |
1025 |
51 |
hydrolase, alpha-beta-hydrolase fold family |
2788 |
2715 |
Not-Attenuated |
Not-Essential |
| J33 |
335 |
220 |
PE family protein |
1233 |
1195 |
Not-Attenuated |
Not-Essential |
| J34 |
869 |
373 |
dioxygenase
|
106 |
97 |
Attenuated |
Essential |
|
| J35 |
434 |
163 |
HP |
3478 |
3370 |
Not-Attenuated |
Not-Essential |
| J36 |
1628 |
228 |
Na+/H+ exchanger
(yjcE)
|
2345 |
2287 |
Not-Attenuated |
Not-Essential |
| J40 |
971 |
445 |
oxidoreductase |
2355 |
2298 |
Not-Attenuated |
Not-Essential |
| J41 |
2654 |
432 |
Conserved HP |
2643 |
2567 |
Moderately-attenauated |
Essential |
|
| J42 |
1523 |
1153 |
aldehyde dehydrogenase |
474 |
458 |
Not-Attenuated |
Not-Essential |
| J134 |
281 |
77 |
Conserved HP |
1376.1 |
1335 |
Not-Attenuated |
Not-Essential |
| J136 |
1952 |
74 |
acyl-CoA dehydrogenase (fadE10) |
896 |
873 |
Not-Attenuated |
Not-Essential |
| J140 |
1601 |
202 |
PE-PGRS protein |
1097 |
1068 |
Not-Attenuated |
Not-Essential |
| J143 |
2888 |
29 |
mmpL family protein, mmpL9 |
2402 |
2339 |
Not-Attenuated |
Not-Essential |
| SM1 |
1238 |
105 |
conserved HP |
214 |
204 |
Attenuated |
Essential |
|
| SM3 |
1046 |
898 |
HP |
2496 |
2423 |
Attenuated |
Essential |
|
| SM4 |
770 |
571 |
transcriptional regulator, TetR family |
489 |
472 |
Moderately-attenauated |
Essential |
|
| G1 |
1583 |
179 |
Virulence factor (HP) |
178 |
169 |
Not-Attenuated |
Not-Essential |
| G2 |
1514 |
739 |
PE_PGRS family protein (PE_PGRS) |
3920 |
3812 |
Not-Attenuated |
Not-Essential |
| G4 |
2189 |
688 |
Lipopolysaccharide biosynthesis protein, WbpC |
1616 |
1565 |
Not-Attenuated |
Not-Essential |
| G7 |
1406 |
796 |
Prolipoprotein diacylglycosyl transferase |
1649 |
1614 |
Not-Attenuated |
Not-Essential |
| G8 |
377 |
202 |
HP |
3776 |
3675 |
Not-Attenuated |
Not-Essential |
| G9 |
1601 |
466 |
PE family protein |
161 |
152 |
Not-Attenuated |
Not-Essential |
| G10 |
1715 |
411 |
AMP binding family protein (fadD11) |
1600 |
1550 |
Not-Attenuated |
Not-Essential |
| G16 |
1289 |
332 |
Transporter, NadC/P/Pho87 family (arsA) |
2758 |
2684 |
Not-Attenuated |
Not-Essential |
| G26 |
380 |
15 |
HP |
2932 |
2863 |
Not-Attenuated |
Not-Essential |
| G28 |
407 |
13 |
HP |
3550 |
3445 |
Not-Attenuated |
Not-Essential |
| G35 |
2243 |
313 |
FtsK/SpoIIIE family protein |
3983 |
3870 |
Not-Attenuated |
Not-Essential |
| G36 |
6335 |
150 |
Mycocerosic acid synthase (mas) |
3010 |
2940 |
Not-Attenuated |
Not-Essential |
| G81 |
1661 |
9 |
Modification methylase |
3363 |
3263 |
Not-Attenuated |
Not-Essential |
| G82 |
293 |
87 |
CBS domain protein |
2478 |
2406 |
Not-Attenuated |
Not-Essential |
| G83 |
1769 |
655 |
HP |
1475 |
1431 |
Not-Attenuated |
Not-Essential |
| G88 |
677 |
245 |
HP |
2548 |
2473 |
Not-Attenuated |
Not-Essential |
| G92 |
1058 |
105 |
Conserved HP |
2202 |
2143 |
Not-Attenuated |
Not-Essential |
| G95 |
1304 |
531 |
amino acid permease (HP) |
544 |
522 |
Not-Attenuated |
Not-Essential |
| G132 |
1349 |
1048 |
P450 heme-thiolate protein |
342 |
327 |
Not-Attenuated |
Not-Essential |
| G139 |
2018 |
618 |
Fatty acid desaturase,ferredoxin reductase |
3658 |
3554 |
Not-Attenuated |
Not-Essential |
| G142 |
425 |
314 |
Conserved HP |
2695 |
2620 |
Not-Attenuated |
Not-Essential |
| G146 |
383 |
236 |
HP |
2778 |
2705 |
Not-Attenuated |
Not-Essential |
| G153 |
272 |
86 |
Exodeoxyribonuclease, small subunit |
1138 |
1107 |
Not-Attenuated |
Not-Essential |
| G154 |
1016 |
722 |
Conserved HP |
3903 |
3796 |
Not-Attenuated |
Not-Essential |
| G157 |
1382 |
530 |
Divalent cation transporter MgtE family (MgtE) |
378 |
362 |
Not-Attenuated |
Not-Essential |
| G161 |
1904 |
418 |
Metallo-beta-lactamase superfamily protein |
3869 |
3762 |
Not-Attenuated |
Not-Essential |
| G163 |
1982 |
1072 |
Cation-transporting ATPase, E1-E2 family |
3851 |
3743 |
Not-Attenuated |
Not-Essential |
| G164 |
563 |
356 |
Conserved HP |
1243 |
1205 |
Not-Attenuated |
Not-Essential |
| G168 |
2903 |
1217 |
mmpL4 |
466 |
450 |
Attenuated |
Essential |
|
| G177 |
1061 |
527 |
Transcriptional regulator, AraC family |
3841 |
3736 |
Not-Attenuated |
Not-Essential |
| G199 |
434 |
326 |
Anti-anti sigma factor |
1955 |
1904 |
Not-Attenuated |
Not-Essential |
| G215 |
710 |
523 |
Oxidoreductase |
3087 |
3007 |
Not-Attenuated |
Not-Essential |
| G224 |
755 |
26 |
acyltransferase family protein |
3924 |
3816 |
Not-Attenuated |
Not-Essential |
| G230 |
410 |
139 |
PiIB-related protein |
2748 |
2673 |
Not-Attenuated |
Not-Essential |
| G254 |
311 |
125 |
HP |
1134 |
1102 |
Not-Attenuated |
Not-Essential |
| G263 |
2762 |
630 |
mmpL7 |
3012 |
2942 |
Not-Attenuated |
Not-Essential |
| G274 |
1181 |
839 |
sugar ABC transporter
(sugC)
|
1276 |
1238 |
Attenuated |
Essential |
|
| G335 |
530 |
350 |
Conserved HP |
2198 |
2140 |
Attenuated |
Essential |
|
| G413 |
1349 |
456 |
HP |
231 |
221 |
Not-Attenuated |
Not-Essential |
| G415 |
1682 |
1091 |
Substrate CoA ligase (fadD2) |
283 |
270 |
Not-Attenuated |
Not-Essential |
| G422 |
440 |
69 |
HP |
2692 |
2617 |
Not-Attenuated |
Not-Essential |
| G433 |
1587 |
953 |
purple acid phosphotase - related protein (HP) |
2654 |
2577 |
Not-Attenuated |
Not-Essential |
| G452 |
1334 |
300 |
PPE family protein |
901 |
878 |
Not-Attenuated |
Not-Essential |
| G460 |
1967 |
714 |
PPE family protein |
1849 |
1800 |
Not-Attenuated |
Not-Essential |
| G466 |
11355 |
1035 |
PPE family protein |
3458 |
3350 |
Not-Attenuated |
Not-Essential |
| G467 |
857 |
528 |
HP |
915 |
891 |
Not-Attenuated |
Not-Essential |
| G474 |
1388 |
742 |
L-asparagine permease |
2186 |
2127 |
Not-Attenuated |
Not-Essential |
| G480 |
1766 |
84 |
PE family protein |
160 |
151 |
Not-Attenuated |
Not-Essential |
| G488 |
1835 |
1604 |
HP |
2981 |
2913 |
Not-Attenuated |
Not-Essential |
| G492 |
1166 |
909 |
Monooxygenase putative |
604 |
575 |
Not-Attenuated |
Not-Essential |
| G500 |
1769 |
655 |
HP |
1475 |
1431 |
Not-Attenuated |
Not-Essential |
| G504 |
476 |
352 |
Conserved HP |
2299 |
2239 |
Attenuated |
Essential |
|
| G520 |
1283 |
1094 |
Thymidine phosphorylase (deoA) |
3415 |
3314 |
Not-Attenuated |
Not-Essential |
| G522 |
893 |
546 |
Thiosulfate sulfurtransferase (sscA) |
3382 |
3283 |
Attenuated |
Essential |
|
| G540 |
2444 |
1853 |
5-methyltetrahydrofolate - homocysteine (metH) |
2183 |
2124 |
Not-Attenuated |
Not-Essential |
| G544 |
1914 |
109 |
Conserved HP |
698 |
669 |
Not-Attenuated |
Not-Essential |
| G545 |
647 |
215 |
HP |
1958 |
1907 |
Not-Attenuated |
Not-Essential |
| G546 |
1232 |
914 |
NADH dehydrogenase I, subunit H (nuoH) |
3240 |
3152 |
Not-Attenuated |
Not-Essential |
| G557 |
465 |
299 |
HP |
2871 |
2803 |
Not-Attenuated |
Not-Essential |
| G566 |
1751 |
954 |
Acyl-CoA-synthase |
2999 |
2930 |
Attenuated |
Essential |
|
| G567 |
452 |
301 |
PPE family protein |
2182.1 |
2123 |
Not-Attenuated |
Not-Essential |
| G532 |
2876 |
1222 |
mmpL1 |
412 |
402 |
Not-Attenuated |
Not-Essential |
| E168 |
2906 |
458 |
mmpL2 |
528 |
507 |
Not-Attenuated |
Not-Essential |
| H446 |
2906 |
2203 |
mmpL2 |
528 |
507 |
Not-Attenuated |
Not-Essential |
| G168 |
2903 |
1217 |
mmpL4 |
466 |
450 |
Attenuated |
Essential |
|
| G868 |
2894 |
1773 |
mmpL5 |
705 |
676 |
Not-Attenuated |
Not-Essential |
| R294 |
2894 |
899 |
mmpL5 |
705 |
676 |
Attenuated |
Essential |
|
| H293 |
1193 |
921 |
mmpL6 |
1608 |
1557 |
Not-Attenuated |
Not-Essential |
| G263 |
2762 |
630 |
mmpL7 |
3012 |
2942 |
Attenuated |
Essential |
|
| R285 |
3269 |
53 |
mmpL8 |
3931 |
3823 |
Attenuated |
Essential |
|
| G476 |
2888 |
29 |
mmpL9 |
2402 |
2339 |
Not-Attenuated |
Not-Essential |
| R61 |
3008 |
2828 |
mmpL10 |
1220 |
1183 |
Attenuated |
Essential |
|
| G46 |
2900 |
560 |
mmpL11 |
212 |
202 |
Attenuated |
Essential |
|
| G107 |
3440 |
349 |
mmpL12 |
1573 |
1522 |
Not-Attenuated |
Not-Essential |
| H353 |
3440 |
772 |
mmpL12 |
1573 |
1522 |
Not-Attenuated |
Not-Essential |
| E262 |
437 |
80 |
mmpS2 |
527 |
506 |
Not-Attenuated |
Not-Essential |
| L6 |
899 |
402 |
mmpS3 |
2254 |
2198 |
Not-Attenuated |
Not-Essential |
| H28 |
2381 |
322 |
GTP pyrophosphokinase (relA) |
2660 |
2583 |
Attenuated |
Essential |
|
| H289 |
752 |
564 |
Conserved HP |
2749 |
2675 |
Not-Attenuated |
Not-Essential |
| H524 |
224 |
106 |
HP |
2606 |
2530 |
Not-Attenuated |
Not-Essential |
| H528 |
389 |
290 |
HP |
1083 |
1052 |
Not-Attenuated |
Not-Essential |
| H545 |
2156 |
664 |
Protease II , ptrBa |
805 |
781 |
Not-Attenuated |
Not-Essential |
| H551 |
1304 |
886 |
conserved HP |
2525 |
2449 |
Not-Attenuated |
Not-Essential |
| H555 |
1619 |
1349 |
virulence factor mce protein |
624 |
594 |
Not-Attenuated |
Not-Essential |
| H556 |
1226 |
138 |
IS 1537 Transposase |
3935 |
3827 |
Not-Attenuated |
Not-Essential |
| H557 |
854 |
296 |
HP |
2803.2 |
2734 |
Not-Attenuated |
Not-Essential |
| H561 |
1241 |
11 |
PE family protein |
2404 |
2340 |
Not-Attenuated |
Not-Essential |
| H562 |
842 |
521 |
hydrolase/esterase, lpqP |
700 |
671 |
Not-Attenuated |
Not-Essential |
| H570 |
179 |
19 |
HP |
933 |
909 |
Not-Attenuated |
Not-Essential |
| H582 |
488 |
261 |
HP |
488 |
471 |
Not-Attenuated |
Not-Essential |
| H615 |
1040 |
334 |
putative esterase, antigen 85-C |
137 |
129 |
Attenuated |
Essential |
|
| H619 |
1080 |
683 |
ABC transporter, ATP binding protein |
684 |
655 |
Attenuated |
Essential |
|
| H790 |
1316 |
180 |
NagC-related protein |
503 |
485 |
Attenuated |
Essential |
|
| H794 |
1391 |
1254 |
nitrite exclusion protein |
280 |
267 |
Not-Attenuated |
Not-Essential |
| H844 |
710 |
280 |
Conserved HP |
2888 |
2821 |
Not-Attenuated |
Not-Essential |
| s14 |
1358 |
376 |
Conserved HP |
2158 |
2097 |
Not-Attenuated |
Not-Essential |
| s16 |
587 |
288 |
HIT family protein |
2688 |
2613 |
Not-Attenuated |
Not-Essential |
| s22 |
1646 |
1355 |
Peptide ABC-transporter (dppD) |
3764 |
3663 |
Not-Attenuated |
Not-Essential |
| s26 |
128 |
73 |
HP |
3145.1 |
3059 |
Not-Attenuated |
Not-Essential |
| s27 |
527 |
62 |
HP (b/w Rv 3142/3143) |
3229 |
xx |
Not-Attenuated |
Not-Essential |
| s36 |
1829 |
482 |
ATPase AAA family |
2175 |
2115 |
Not-Attenuated |
Not-Essential |
| s39 |
935 |
31 |
Integrase/recombinase XerD |
1740 |
1701 |
Not-Attenuated |
Not-Essential |
| s41 |
1580 |
1043 |
MgmE/PrPD family protein |
1162 |
1130 |
Not-Attenuated |
Not-Essential |
| s43 |
1829 |
893 |
ATPase AAA family |
2175 |
2115 |
Not-Attenuated |
Not-Essential |
| s45 |
2538 |
2227 |
HP |
4022 |
3903 |
Not-Attenuated |
Not-Essential |
| s48 |
230 |
43 |
HP |
694 |
666 |
Attenuated |
Essential |
|
| s49 |
770 |
256 |
transcriptional regulator, TetR family |
489 |
472 |
Attenuated |
Essential |
|
| s51 |
293 |
211 |
Conserved HP |
529 |
508 |
Not-Attenuated |
Not-Essential |
| s52 |
1778 |
1132 |
oxidoreductase, short chain |
2270 |
2214 |
Not-Attenuated |
Not-Essential |
| s53 |
1525 |
1019 |
HP |
4001 |
3886 |
Not-Attenuated |
Not-Essential |
| s55 |
1076 |
934 |
magnesium chelatase, putative |
3794 |
3692 |
Not-Attenuated |
Not-Essential |
| s57 |
1004 |
326 |
4-hydroxy-2-oxovalerate aldolase |
3575 |
3469 |
Not-Attenuated |
Not-Essential |
| s59 |
1697 |
1467 |
2,3-dihydroxybenzoate- AMP ligase |
2452 |
2384 |
Not-Attenuated |
Not-Essential |
| s63 |
1523 |
862 |
Proteinase, putative |
2282 |
2224 |
Attenuated |
Essential |
|
| s67 |
962 |
511 |
D-amino acid oxidase (aao) |
1956 |
1905 |
Not-Attenuated |
Not-Essential |
| s80 |
1553 |
1115 |
Glycerolkinase (glpK) |
3798 |
3696 |
Not-Attenuated |
Not-Essential |
| R23 |
1271 |
658 |
Lipoprotein (lppF) |
1972 |
1921 |
Not-Attenuated |
Not-Essential |
| R35 |
845 |
1 |
HP (b/w Rv3027/3028) |
3111 |
3027 |
Not-Attenuated |
Not-Essential |
| R53 |
1598 |
348 |
Very-long-chain acyl-CoA-synthetase (fadD1) |
1793 |
1750 |
Not-Attenuated |
Not-Essential |
| R64 |
902 |
442 |
HP |
541 |
519 |
Not-Attenuated |
Not-Essential |
| R66 |
950 |
692 |
Conserved HP |
2156 |
2095 |
Not-Attenuated |
Not-Essential |
| R83 |
1544 |
1105 |
phospholipase C (plcD) |
1799 |
1755 |
Not-Attenuated |
Not-Essential |
| R92 |
1940 |
18 |
Exinuclease ABC, subunit C (uvrC) |
1463 |
1420 |
Not-Attenuated |
Not-Essential |
| R97 |
401 |
117 |
Conserved HP |
3230 |
3143 |
Not-Attenuated |
Not-Essential |
| R161 |
2363 |
571 |
Arylsulfatase (atsD) |
692 |
663 |
Not-Attenuated |
Not-Essential |
| R164 |
344 |
172 |
transcriptional regulatorArsR family (HP) |
88 |
81 |
Not-Attenuated |
Not-Essential |
| R169 |
1463 |
22 |
Aldehyde dehydrogenase family protein |
233 |
223 |
Not-Attenuated |
Not-Essential |
| R175 |
1346 |
480 |
amino
acylase-1, putative (dapE2)
|
2199 |
2141 |
Not-Attenuated |
Not-Essential |
| R181 |
3441 |
1124 |
HP |
1290 |
1251 |
Not-Attenuated |
Not-Essential |
| R182 |
1424 |
1132 |
Conserved HP |
3352 |
3254 |
Not-Attenuated |
Not-Essential |
| R189 |
1202 |
810 |
Non-specific lipid transfer protein (ltp1) |
2860 |
2790 |
Not-Attenuated |
Not-Essential |
| R197 |
2171 |
102 |
HP |
3993 |
3879 |
Not-Attenuated |
Not-Essential |
| R204 |
1406 |
1039 |
oxidoreductase, pyridine nucleotide-disulphide |
2786 |
2713 |
Not-Attenuated |
Not-Essential |
| R208 |
1034 |
585 |
IS1603 transposase |
3281 |
3191 |
Not-Attenuated |
Not-Essential |
| R220 |
998 |
304 |
Cation efflux system protein (HP) |
2084 |
2025 |
Not-Attenuated |
Not-Essential |
| R223 |
1319 |
143 |
HP |
465 |
449 |
Not-Attenuated |
Not-Essential |
| R235 |
1037 |
355 |
Parathion hydrolase (HP) |
240 |
230 |
Not-Attenuated |
Not-Essential |
| R237 |
1619 |
601 |
Chaperonin 69kDa (groEL1) |
3526 |
3417 |
Attenuated |
Essential |
|
| R240 |
1145 |
212 |
N5, N10 methylenetetrahydromethanopterin reductase related protein
|
3025 |
2951 |
Not-Attenuated |
Not-Essential |
| R243 |
1511 |
1221 |
HP |
350 |
336 |
Attenuated |
Essential |
|
| R245 |
1163 |
262 |
Glycosyl transferase |
1250 |
1212 |
Not-Attenuated |
Not-Essential |
| R252 |
2174 |
1612 |
4-a-gluconotransferase |
1831 |
1781 |
Attenuated |
Essential |
|
| R253 |
1073 |
481 |
GTP binding protein |
1143 |
1112 |
Not-Attenuated |
Not-Essential |
| R254 |
674 |
9 |
RNA
polymerase sigma 70 factor, ECF family
|
3523 |
3414 |
Not-Attenuated |
Not-Essential |
| R258 |
1145 |
932 |
HP |
3793 |
3691 |
Not-Attenuated |
Not-Essential |
| R259 |
830 |
466 |
Conserved HP |
4004 |
3889 |
Not-Attenuated |
Not-Essential |
| R265 |
1151 |
949 |
HP |
3632 |
3529 |
Not-Attenuated |
Not-Essential |
| R266 |
1646 |
518 |
Substrate CoA-ligase, putative (fadD19) |
3616 |
3515 |
Not-Attenuated |
Not-Essential |
| R268 |
392 |
268 |
HP |
2944 |
2877 |
Not-Attenuated |
Not-Essential |
| R274 |
212 |
67 |
Conserved HP |
3853 |
3745 |
Not-Attenuated |
Not-Essential |
| R275 |
1775 |
630 |
ABC transporter, ATP-binding protein (HP) |
1707 |
1668 |
Not-Attenuated |
Not-Essential |
| R277 |
698 |
441 |
HP |
3769 |
3668 |
Not-Attenuated |
Not-Essential |
| R284 |
1223 |
91 |
Acyl-CoA-dehydrogenase, putative (fadE2) |
163 |
154 |
Not-Attenuated |
Not-Essential |
| R287 |
1682 |
515 |
Indolepyruvate decarboxylase, putative |
876 |
853 |
Attenuated |
Essential |
|
| R289 |
2063 |
1 |
Drug transporter (HP) |
1926 |
1877 |
Not-Attenuated |
Not-Essential |
| R295 |
644 |
35 |
HP |
3808 |
3705 |
Not-Attenuated |
Not-Essential |