TARGET Research Results
Details
DescriptionPROBABLE GLUTAMINE SYNTHETASE GLNA2 (GLUTAMINE SYNTHASE) (GS-II)
Accession numberRv2222c
Gene nameglnA2
Gene length1341
Protein length446
Coordinates2492402..2493742
Orientation-
Molecular mass49607.65
Isoelectric point5.21

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU2222c-1038[no data]
JHU2222c-1093Not-Attenuated
JHU2222c-647[no data]
JHU2222c-382[no data]
JHU2222c-1291[no data]
JHU2222c-1094[no data]
 

CDC1551 Homolog
ORFMT2280
Essentiality Prediction
Sassetti et al, 2003*[no data]

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU2222c-1038MT2280Rv2222c10381341yes
JHU2222c-647MT2280Rv2222c6471341no (will be available later)
JHU2222c-1094MT2280Rv2222c10941341yes
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]