TARGET Research Results
Details
DescriptionPROBABLE GTP-BINDING PROTEIN LEPA (GTP-BINDING ELONGATION FACTOR)
Accession numberRv2404c
Gene namelepA
Gene length1962
Protein length653
Coordinates2701287..2703248
Orientation-
Molecular mass72363.53
Isoelectric point5.51

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU2404c-1478[no data]
JHU2404c-1447[no data]
JHU2404c-1264[no data]
 

CDC1551 Homolog
ORFMT2476
Essentiality Prediction
Sassetti et al, 2003*non-essential

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU2404c-1478MT2476Rv2404c14781962no (will be available later)
JHU2404c-1447MT2476Rv2404c14471962no (will be available later)
JHU2404c-1264MT2476Rv2404c12641962yes
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]