TARGET Research Results
Details
DescriptionCONSERVED HYPOTHETICAL INTEGRAL MEMBRANE PROTEIN YRBE4B. Possible ABC transporter.
Accession numberRv3500c
Gene nameyrbE4B
Gene length843
Protein length280
Coordinates3919220..3920062
Orientation-
Molecular mass29563.37
Isoelectric point8.37

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU3500c-687[no data]
JHU3500c-688[no data]
JHU3500c-515[no data]
JHU3500c-687[no data]
JHU3500c-286[no data]
JHU3500c-692[no data]
 

CDC1551 Homolog
ORFMT3604
Essentiality Prediction
Sassetti et al, 2003*non-essential

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU3500c-688MT3604Rv3500c688843yes
JHU3500c-515MT3604Rv3500c515843no (will be available later)
JHU3500c-687MT3604Rv3500c687843no (will be available later)
JHU3500c-286MT3604Rv3500c286843yes
JHU3500c-692MT3604Rv3500c692843yes
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]