Reagents Supporting Avian Influenza Research


A multi-state outbreak of Highly Pathogenic Avian Influenza (HPAI) A(H5N1) bird flu in dairy cows was initially reported on March 25, 2024. This marks the first time that these avian influenza viruses have been detected in cattle.

The Centers for Disease Control and Prevention (CDC) confirmed one human HPAI A(H5N1) clade infection which occurred in an individual with exposure to dairy cattle in Texas that were presumed to be infected with the virus.12  Although such transmission is considered rare, this case represents the first instance of likely mammal-to-human transmission of the HPAI A(H5N1) avian influenza virus.

It is crucial to monitor and track the outbreak to better understand the risks associated with avian influenza and its potential impact on both animals and humans. BEI Resources is offering purified HA and NA proteins from (H5N1) clade virus and LPAI H5N1 irradiated virus. These materials can be used in a variety of serological, broader immunological and biochemical assays related to H5N1 influenza.2, 3


BEI Resources 

Single-Lineage Malaria Clones

NR-59421  Influenza A Virus, A/mallard/Wisconsin/2576/2009 (H5N1), Tissue Culture Adapted, in Madin-Darby Canine Kidney Cells, Gamma-Irradiated
NR-59424  H5 Hemagglutinin Protein from Influenza A Virus, A/bald eagle/Florida/W22- 134-OP/2022 (H5N1), Recombinant from Baculovirus
NR-59476  N1 Neuraminidase Protein from Influenza A Virus, A/bald eagle/Florida/W22-134-OP/2022 (H5N1), Recombinant from Baculovirus


Three influenza A (H5N1/bird flu) virus particles (rod-shaped; purple)



1. "Current H5N1 Bird Flu Situation in Dairy Cows." Centers for Disease Control and Prevention, Accessed 08 May 2024.

2. Burrough, E. R., et al. “Highly Pathogenic Avian Influenza A(H5N1) Clade Virus Infection in Domestic Dairy Cattle and Cats, United States, 2024.” Emerg. Infect. Dis. 30 (2024). doi.10.3201/eid3007.240508. PubMed: 38683888. Online ahead of print.

3. Feldmann, F., et al. “Gamma Irradiation as an Effective Method for Inactivation of Emerging Viral Pathogens.” Am. J. Trop. Med. Hyg. 100 (2019): 1275-1277. PubMed: 30860018.

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