Irradiated Monkeypox clade 1b Lysate Now Available

Monkeypox virus (MPXV), scientifically classified as Orthopoxvirus monkeypox, is a double-stranded enveloped DNA virus and a member of the Orthopoxvirus genus of the Poxviridae family. MPXV is divided into two distinct genetic clades: clade I, previously referred to as the Congo Basin or Central African clade, which includes sub-clades Ia and Ib; and clade II, formerly known as the West African clade, comprising sub-clades IIa and IIb. [1]

During a global clade II outbreak, the Democratic Republic of the Congo reported an emergence of clade Ib in 2023, which has since spread beyond endemic regions, prompting increased surveillance and diagnostic needs. [2] Since November 2024, ten cases of clade I MPXV have been reported in the U.S., including three cases in October 2025 with no recent travel history. [3,4]

BEI Resources is now offering an irradiated lysate of MPXV clade Ib virus from a returning traveler that can be used in molecular assays to complement two products, gDNA and heat-killed virus, which will be available soon.

 Irradiated Mpox virus

References:

1. “Factsheet for Health Professionals on Mpox.” European Centre for Disease Prevention and Control, https://www.ecdc.europa.eu/en/all-topics-z/monkeypox/factsheet-health-professionals. Accessed 26 February 2026.

2. “First Clade Ib Monkeypox Virus Infection Reported in the Americas — California, November 2024.” Centers for Disease Control and Prevention. https://www.cdc.gov/mmwr/volumes/74/wr/mm7404a1.htm. Accessed 26 February 2026.

3. Tang, E. C., et al. “Detection of Community Transmission of Clade Ib Mpox Virus in the United States.” NEJM Evid. 5 (2026): 10.1056/EVIDpha2500319.

4. “Monkeypox in the United States and Around the World: Current Situation.” Centers for Disease Control and Prevention, https://www.cdc.gov/monkeypox/situation-summary/index.html. Accessed 26 February 2026.

Image Alt Text: Colorized transmission electron micrograph of mpox virus particles (green) found within infected VERO E6 cells (blue). The virus particles are in various stages of maturity, which accounts for differences in shape. Credit: NIAID (NIAID/CC BY 2.0)

Image Credit: Colorized TEM of mpox virus particles. Credit: NIAID (NIAID/CC BY 2.0)