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New HIV-1 Subtype A/AC Panel for Therapeutic Development
HIV-1 transmitted/founder (T/F) viruses represent the initial viral strains that establish infection following transmission and play a crucial role in understanding HIV pathogenesis.[1] These viruses provide invaluable insights into the early immune evasion strategies employed by HIV, guiding the development of therapeutic interventions to enhance host immune responses. Understanding T/F viruses also informs public health strategies by clarifying how different transmission modes influence viral evolution and dynamics. Overall, the study of HIV-1 T/F viruses offers critical insights into the initial stages of HIV infection and identifies potential targets for treatments and therapies.
A collection of 18 HIV-1 infectious molecular clones (IMCs) representing subtype A and AC transmitted founder viruses that circulated in sub-Saharan Africa were constructed from the IAVI Rwandan Protocol C acute infection cohort.[2] The panel features fully sequenced clones with comprehensive phenotypic characterization, including replication capacity, infectivity profiles, CCR5 tropism, and neutralization sensitivity patterns.
This panel of well-characterized subtype A and AC will facilitate studies on the development of potential HIV-1 treatments. Five IMCs from this panel are currently available on the BEI Resources catalog. The remaining twelve IMCS (HRP-20370, HRP-20374 to HRP-20385) will be available soon.
Transmitted/Founder Infectious Molecular Clones
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BEI Item No.
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Description
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| HRP-20368 |
HIV-1 Infectious Molecular Clone, 175019/pGEM-5Zf(+) |
| HRP-20369 |
HIV-1 Infectious Molecular Clone, 175014/pGEM-5Zf(+) |
| HRP-20371 |
HIV-1 Infectious Molecular Clone, 175005/pGEM-5Zf(+) |
| HRP-20372 |
HIV-1 Infectious Molecular Clone, 175012/pGEM-5Zf(+) |
| HRP-20373 |
HIV-1 Infectious Molecular Clone, 175010/pGEM-5Zf(+) |
 330X660_1.jpg "Colorized transmission electron micrograph of an HIV-1 virus particle (yellow/gold) budding from the plasma membrane of an infected H9 T cell (purple/green)")
References:
1. Joseph, S. B. et al. “Bottlenecks in HIV-1 Transmission: Insights from the Study of Founder Viruses.” Nat. Rev. Microbiol. 13 (2015): 414-425, PubMed: 26052661.
2. Yue, L., et al. "Phenotypic Characterization of Subtype A and Recombinant AC Transmitted/Founder Viruses from a Rwandan HIV-1 Heterosexual Transmission Cohort." Viruses. 16 (2024): 1706. PubMed: 39599821.
Image Alt Text: Scanning electromicrograph of an HIV-infected T cell. Credit: NIAID (NIAID/CC BY 2.0)
Image Credit: Scanning electromicrograph of an HIV-infected T cell. Credit: NIAID (NIAID/CC BY 2.0)
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