The extensive collection of Mycobacterium species available from BEI Resources continues to grow with the addition of M. ulcerans, the cause of a neglected tropical disease known as Buruli ulcer that causes cutaneous lesions and osteomyelitis.1,2,3 M. ulcerans has been identified in 33 countries worldwide, most commonly in Africa, and typically occurs in wetland and tropical regions and in areas with recent environmental change.2 M. ulcerans contains a virulence plasmid encoding for the production of mycolactone, a macrocyclic polyketide toxin with cytotoxic and immunosuppressive activity.
The available and upcoming isolates were collected from clinical cases of Buruli ulcer in Benin, where over 6,000 Buruli ulcer cases were reported between 2006 and 2015.4
|BEI Resources No.
||Mycobacterium ulcerans, Strain S4018
||Mycobacterium ulcerans, Strain Benin UB 502/08 - In Pre-Production
||Mycobacterium ulcerans, Strain Benin UB 343/08 - In Pre-Production
||Mycobacterium ulcerans, Strain Benin UB 609/08 - In Pre-Production
- Röltgen, K., T. P. Stinear and G. Pluschke. “The Genome, Evolution and Diversity of Mycobacterium ulcerans.” Infect. Genet. Evol. 12 (2012): 522-529. PubMed: 22306192.
- Merritt, R. W., et al. “Ecology and Transmission of Buruli Ulcer Disease: A Systematic Review.” PloS Negl.Trop. Dis. 4 (2010): e911. PubMed: 21179505.
- Pommelet, V., et al. “Findings in Patients from Benin with Osteomyelitis and Polymerase Chain Reaction-Confirmed Mycobacterium ulcerans Infection.” Clin. Infect. Dis. 59 (2014): 1256-1264. PubMed: 25048846.
- Degnonvi, H., et al. “Effect of Well Drilling on Buruli Ulcer Incidence in Benin: A Case-Control, Quantitative Survey.” Lancet Planet Health 3 (2019): e349-e356. PubMed: 31439316.
Image: Mycobacterium ulcerans, strain S4018 (NR-51701) on Lowenstein-Jensen agar (BEI Resources)