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ARP-11580, is no longer available. Maraviroc (Brand name: Selzentry), is now available as HRP-11580. Chemical Name: 4,4-difluoro-N-{(1S)-3-[3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)- 8-azabicyclo[3.2.1]oct-8-yl]-1- phenylpropyl}cyclohexanecarboxamide Empirical Formula: C29H41F2N5O Molecular Weight: 513.7 g/mol CAS Number: 376348-65-1 Maraviroc (Selzentry) is an entry inhibitor. Specifically, maraviroc blocks the chemokine receptor CCR5 which HIV uses as a coreceptor to bind and enter a human helper T cell. Because HIV can also use another coreceptor, CXCR4, an HIV tropism test such as a trofile assay must be performed to determine if the drug will be effective. Each vial of ARP-11580 contains approximately 20 mg of Maraviroc (Selzentry). Please refer to the appropriate data sheet for lot-specific information. Note: ARP-11580 is highly soluble across the pH range of 1 to 7.5. Once resuspended, working aliquots can be stored at -20°C. CAUTION: Toxicological properties are not fully understood. Use in fume hood or well ventilated area. Individuals must use prudent practices when handling or using this compound. Store in sealed containers. This material is for experimental purposes only.
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