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MRA-1161  Chemical

, DSM1

(Antimicrobial Compounds and Other Chemicals)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: DSM1
Organism: Chemical

Biosafety Level: 1
Availability Status: Temporarily Out of Stock (Please See Comments)
Store at: Room temperature (store solubilized aliquots at -20°C or colder)
Contributor: MR4
Comments:
Quantity limit per order for this item is 1. This item can be ordered once a year.

This item is currently in our production queue. Please allow ample time for distribution lots to be made available.

DSM1, or "compound 7", has the chemical name of 5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-yl)naphthalen-2-ylamine. It is an experimental antimalarial lead compound, active against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).

Each vial of MRA-1161 contains approximately 0.5 g of DSM1 powder. DSM1 is soluble in DMSO and insoluble in water. 

Phillips, M. A., et al. "Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitors with Potent and Selective Activity against the Malaria Parasite, Plasmodium falciparum." J. Med. Chem. 51 (2008): 3649-3653. PubMed: 18522386.
Phillips, M. A. and P. K. Rathod. "Plasmodium Dihydroorotate Dehydrogenase: A Promising Target for Novel Anti-Malarial Chemotherapy." Infect. Disord. Drug Targets 10 (2010): 226-239. PubMed: 20334617.
Deng, X., et al. "Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds." J. Biol. Chem. 284 (2009): 26999-27009. PubMed: 19640844.
Gujjar, R., et al. "Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice." J. Med. Chem. 52 (2009): 1864-1872. PubMed: 19296651.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: DSM1, MRA-1161."
Additional Information: MRA-1161 Safety Data Sheet
PERMITS
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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BEI Resources products are intended for laboratory research purposes only. They are not intended for use in humans.

While BEI Resources uses reasonable efforts to include accurate and up-to-date information on this site, BEI Resources makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. BEI Resources does not warrant that such information has been confirmed to be accurate.


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