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NR-51636  Mycobacterium tuberculosis, Delamanid (Reference Standard)
(Antimicrobial Compounds and Other Chemicals)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Delamanid (Reference Standard)
Organism: Mycobacterium tuberculosis
Biosafety Level: 1
Availability Status: In Stock
Store at: Room temperature, protected from light
Contributor: N Hariguchi
Comments:
Quantity limit per order for this item is 1. This item can be ordered twice a year.

NR-51636 is subject to the Material Transfer Agreement Registration Addendum attached to the Additional Information section below. NR-51636 may not be used for commercial purposes. It may only be used for in vitro studies of mycobacteria drug susceptibility testing, in vitro pharmacokinetic/pharmacodynamic studies including the Hollow Fiber System (HFS) and/or animal studies of mycobacterial infection models.


Delamanid (OPC-67683; Deltyba™) is a bicyclic nitro-imidazooxazole compound shown to be effective against Mycobacterium tuberculosis (M. tuberculosis), through inhibiting the synthesis of key mycolic acids. Among TB drugs, delamanid has the lowest minimum inhibitory concentration (MIC) against both drug-susceptible and drug-resistant M. tuberculosis isolates, and is active against replicating and dormant, extracellular and intracellular bacilli. In clinical studies, delamanid demonstrated significant improvement of sputum culture conversion with two months of treatment in combination with an optimized background regimen for pulmonary multidrug-resistant (MDR)-TB adult patients, as compared to treatment with placebo. Spontaneous resistance frequencies to delamanid were similar to those of isoniazid and PA-824.

Each vial contains approximately 20 mg of delamanid.

For research use only. Not for human use.
Citations: Acknowledgment for publications should read “The following reagent was obtained through BEI Resources, NIAID, NIH: Delamanid (Reference Standard), NR-51636.”
Additional Information: Material Transfer Agreement Registration Addendum
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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BEI Resources products are intended for laboratory research purposes only. They are not intended for use in humans.

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