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Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Antibody Class: IgG?
ARP-12348 is a recombinant monoclonal antibody to SIVmac239 gp41, (ERKVDFLEEQI) produced in a 293-6E cell expression system and purified by Protein A chromatography. The antibody was isolated from a rhesus monkey infected with SIVmac239-gp41/g23 (SIVmac239 lacking the second and third glycosylation sites of gp41).
ARP-12348 demonstrates high binding to SIVmac239 gp41/g23 and gp160 by ELISA and Western blot but little or none to wild-type SIVmac239 gp41 and gp160.
ARP-12348 neutralizes SIVmac239-gp41/g23 virus but not wild-type SIVmac239.
ARP-12348 has a titer of 1:81,000 against SIVmac239 gp41 (ARP-12459).
Note: ARP-12348 may be stored at 4°C for short-term storage and at -80°C for long term storage. Avoid freeze-thaw cycles as reagent degradation may result.
Each vial of ARP-12348 contains approximately 100 µg of sterile-filtered, purified antibody at 1 mg per mL in PBS pH 7.2. Please refer to the appropriate data sheet for lot-specific information.
Martinez-Navio, J. M. and R. C. Desrosiers. “Neutralizing Capacity of Monoclonal Antibodies that Recognize Peptide Sequences Underlying the Carbohydrates on gp41 of Simian Immunodeficiency Virus.” J. Virol. 86 (2012): 12484-12493. PubMed: 22993152.
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