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MRA-1002   Plasmodium falciparum, Strain SB1-A6
(Parasitic Protozoa)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Organism: Plasmodium falciparum
Designations: Plasmodium falciparum, Strain SB1-A6
Biosafety Level: 2
Availability Status: In Stock
Store at: Liquid nitrogen vapor phase
Contributor: M Smilkstein
Quantity limit per order for this item is 1. This item can be ordered once a year. Orders over this limit will be sent to NIAID for approval before shipment.

Plasmodium falciparum, strain SB1-A6 was resistant to all tested inhibitors of cytochrome bc1 electron transport. Clone SB1-A6 was drug selected from parental P. falciparum D6 using 3-(6,6,6-trifluorohexyloxy)-6-aminoacridone; the parasite lacks requirement for electron transport through the cyt bc1 complex. Typically, in vitro dose-response to cytochrome bc1 inhibitors (e.g., atovaquone) is biphasic, with partial growth inhibition evident at very low concentrations (e.g., 1-5 nM for atovaquone) with additional growth inhibition only at very high concentrations (e.g., 25 micromolar for atovaquone). The basis for the biphasic response is unknown, but it does not appear to be the result of a mixed parasite population.

Smilkstein, M. J., et al. "A Drug-Selected Plasmodium falciparum Lacking the Need for Conventional Electron Transport." Mol. Biochem. Parasitol. 159 (2008): 64-68. PubMed: 18308406.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Plasmodium falciparum, Strain SB1-A6, MRA-1002, contributed by Martin J. Smilkstein."
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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