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NR-722  SARS coronavirus, Spike (S) Protein deltaTM, Recombinant from Baculovirus
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Description: Spike (S) Protein deltaTM, Recombinant from Baculovirus
Organism: SARS coronavirus
Biosafety Level: 1
Availability Status: In Stock
Store at: -20°C or colder
Contributor: NIH Biodefense and Emerging Infections Research Resources Repository
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

NR-722 is a truncated, glycosylated recombinant form of the SARS-CoV spike (S) external envelope glycoprotein. A 60-amino acid deletion of the transmembrane domain (deltaTM) was made to the C-terminal end of the protein. A baculovirus signal sequence, MPLYKLLNVLWLVAVSNA, was added to the N-terminal end of the protein to enhance expression. The SARS-CoV spike (S) protein deltaTM was produced in Sf9 insect cells using a baculovirus expression vector system and was purified using conventional chromatographic techniques. The baculovirus signal sequence is efficiently removed during translocation of the protein across the membrane. The resulting protein, NR-722, has a molecular weight of approximately 150,000 daltons. The purified protein was demonstrated to be functionally active based on its ability to bind to a recombinant form of its functional receptor, angiotensin I converting enzyme-2.

Each vial contains approximately 1 mg of NR-722 in 2.5 mM sodium phosphate (pH 7.2) and 150 mM NaCl.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: SARS-CoV Spike (S) Protein deltaTM, Recombinant from Baculovirus, NR-722."
Publications Citing
this Reagent:
Andonov, A. "Neutralizing Epitopes of the SARS-CoV S-Protein Cluster Independent of Repertoire, Antigen Structure or mAb Technology." Mabs. 2 (2010):53-66. PubMed: 20168090.
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

SARS coronavirus Spike (S) Protein with C-terminal Histidine Tag, Recombinant from Baculovirus
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