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Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.
Brucella melitensis (B. melitensis), strain 16MΔvjbR is attenuated for virulence in mice and small ruminants through modification of B. melitensis, strain 16M, following passage in a Spanish goat. The parent strain, 16M (BEI Resources NR-256, ATCC ® 23456™) was isolated from an infected goat by the Bureau of Animal Industry in Washington, DC and deposited to ATCC ® in 1967 by Dr. W. J. Brinley-Morgan, Head, Diseases of Breeding Department, The Central Veterinary Laboratory, Ministry of Agriculture, Fisheries and Food, New Haw, Weybridge, Surrey, England.
B. melitensis, strain 16MΔvjbR contains a deletion of the vjbR gene which prevents expression of VirB, thus rendering the strain avirulent in mice and susceptible to death in phagocytes. The vjbR gene (locus BMEII1116) encodes the luxR-like quorum-sensing-related transcriptional regulator. Strain 16MΔvjbR is non-lethal to immunocompromised mice and does not cause abortion in pregnant sheep or fever in Rhesus macaques. The complete genome sequence of the parent strain, B. melitensis, strain 16M, is available (GenBank: AE008917 and AE008918).
B. melitensis, strain 16MΔvjbR is excluded from Select Agent status. Please refer to the Select Agent Exclusions at the Federal Select Agent Program website for more information.
Each vial contains approximately 0.7 mL of bacterial culture in Tryptic Soy broth supplemented with 10% glycerol.
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