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BEI Resources currently limits the total number of "Made to Order" items which can be ordered by a registrant to 10 "Made to Order" items per 6 month period. Please check the Availability Status on the items you are ordering and limit orders appropriately.
NR-166  Coccidioides posadasii, Δcts2ard1cts3
Price: All BEI Resources products are provided
at no cost to registered researchers.
Organism: Coccidioides posadasii
Designations: Δcts2ard1cts3
Biosafety Level: 2
Availability Status: In Stock
Store at: -70°C or colder
Contributor: University of Toledo and California State University
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

NR-166 was derived from Coccidioides posadasii (C. posadasii) strain C735 by deletion of two chitinase genes (cts2 and cts3) and a D-arabinitol 2-dehydrogenase gene (ard1).

This attenuated strain can transform into first generation spherules, but it is incapable of endosporulation, and therefore, cannot reproduce in the parasitic form of the fungus, rendering it avirulent. Avirulence of the Δcts2ard1cts3 strain was confirmed through a murine model of coccidioidomycosis. The whole genome shotgun sequence of C. posadasii C735 ΔSOWgp [a transgenic strain of C. posadasii C735 that has had the spherule outer wall glycoprotein (SOWgp) gene deleted] is available (GenBank: ACFW00000000.).

Each vial of NR-166 contains approximately 1 mL of fungal culture containing 10% DMSO.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Coccidioides posadasii, Δcts2ard1cts3, NR-166."
For a list of permits that may be required for shipping this product and to set the permit information preferences; please select a country from the drop down below.

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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