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NR-21657  Influenza A virus, A/FPV/Dutch/1927 (H7N7)
(Viruses)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: A/FPV/Dutch/1927 (H7N7)
Organism: Influenza A virus
Biosafety Level: 3
Availability Status: In Stock
Store at: -60°C or colder
Contributor: RJ Webby
Comments:
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

The details of the isolation and history of influenza A virus, A/FPV/Dutch/1927 (H7N7) are not clear. Although the "Dutch" strain of fowl plague virus (FPV) is reported to have been isolated from a chicken in Indonesia in 1927 or 1928, and transferred to the Central Veterinary Laboratory, Weybridge, Surrey, England via the Netherlands, the fact that there was an outbreak of fowl plague in the Netherlands in 1927 calls this claim into question. In any case, this virus is representative of classical FPV, first identified as influenza A by Schäfer in 1955. A so-called "Dobson" variant of the Dutch strain is also frequently referenced in the literature. Although it seems likely that all of the FPV strains variously called "Dobson," "Dutch," and "Dobson/Dutch" did, in fact, originate from the same primary isolate, some potentially important genotypic and phenotypic differences have been noted. A review of the information available from the contributor, the literature, and the databases suggests that NR-21657 may well be the Dobson variant.

Sequence information is available for influenza A virus, A/FPV/Dutch/1927 (H7N7) at the Influenza Research Database.

NR-21657 is a confirmed highly pathogenic avian influenza virus (HPAI), meeting the criterion of a multi-basic amino acid sequence with a minimum of b-x-b-r (basic-any-basic-arginine) in the hemagglutinin cleavage site.

Each vial contains approximately 1 mL of pooled allantoic fluid from specific-pathogen free (SPF) embryonated chicken eggs infected with influenza A virus, A/FPV/Dutch/1927(H7N7).

Note: If homogeneity is required for your intended use, please purify prior to initiating work.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Influenza A Virus, A/FPV/Dutch/1927 (H7N7), NR-21657."
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
  • USDA APHIS VS 16-6 or 16-6A permit must be obtained and a copy of the permit must be sent to ATCC in advance of shipment. The Application Form VS 16-3 (Import controlled material import or transport organisms or vectors) must be submitted to USDA APHIS Veterinary Services to obtain the VS 16-6 or 16-6A permit.
  • Select Agents require facility registration for specific agents with CDC and completion of APHIS/CDC Form 2. For information about toxin amounts excluded from CDC Select Agent regulations, click here.

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