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NR-3617  Influenza A virus, Kilbourne F140: A/New Jersey/11/1976 (HA, NA) x A/Puerto Rico/8/1934 (H1N1), Reassortant/Mutant X-53a (CL), High (H) Yield
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Description: Kilbourne F140: A/New Jersey/11/1976 (HA, NA) x A/Puerto Rico/8/1934 (H1N1), Reassortant/Mutant X-53a (CL), High (H) Yield
Organism: Influenza A virus
Biosafety Level: 2
Availability Status: In Stock
Store at: -60°C or colder
Contributor: NIAID/NIH
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

NR-3617 was biologically cloned from reassortant/mutant X53a (Kilbourne F139; BEI Resources NR-3581) by limiting dilution passage in embryonated chicken eggs. X-53a, in turn, is a high yield hemagglutinin mutant that was derived by selective passage of X-53 (Kilbourne F128; BEI Resources NR-3664) in the presence of "L" variant-suppressive antiserum. X-53 is A/New Jersey/11/1976 (HA, NA) x A/Puerto Rico/8/1934 (H1N1).

NR-3617 exhibits a true high yield (H) biologic phenotype in vitro. The HA and NA genes of NR-3617 are definitively derived from influenza A/New Jersey/11/1976 (H1N1), a human isolate recovered during the 1976 swine flu epidemic at Fort Dix, NJ. All other genes are from A/Puerto Rico/8/1934 (H1N1). Uncloned X-53a was used for mass immunization of over 40 million people in the 1976 National Immunization Program against swine flu. The derivation and properties of various A/New Jersey/11/1976 (H1N1) reassortants, as well as cloned derivatives, mutants, and re-reassortants thereof, have been described in detail.

Each vial contains approximately 1 mL of pooled allantoic fluid from specific pathogen free (SPF) embryonated chicken eggs infected with cloned, high yield, reassortant/mutant influenza A virus, A/New Jersey/11/1976 (HA, NA) x A/Puerto Rico/8/1934 (H1N1).

Kilbourne Archive Homepage
Kilbourne/New York Medical College Archive of Influenza Virus Reassortants and Mutants
Kilbourne F140 information
Download (Word Docs):Detailed Description
File Number:F140
Virus Name:
Virus Attributes:Type A Virus. A subtype H1N1. reassortant . mutant . human HA-specific antigenic hybrid . high yield reassortants
AntiserumImmunizing VirusLocationAntiserum Attributes
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Kilbourne F140: A/New Jersey/11/1976 (HA, NA) x A/Puerto Rico/8/1934 (H1N1), Reassortant/Mutant X-53a (CL), High (H) Yield, NR-3617."
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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