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NR-3642  Influenza A virus , Kilbourne F174: A/turkey/Massachusetts/3740/1975 (HA) x A/Taiwan/1/1986 (NA) x A/Puerto Rico/8/1934 (H6N1), Reassortant X-94
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Description: Kilbourne F174: A/turkey/Massachusetts/3740/1975 (HA) x A/Taiwan/1/1986 (NA) x A/Puerto Rico/8/1934 (H6N1), Reassortant X-94
Organism: Influenza A virus
Biosafety Level: 2
Availability Status: In Stock
Store at: -60°C or colder
Contributor: NIAID/NIH
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

NR-3642 is a neuraminidase (NA)-specific antigenic hybrid developed by crossing influenza A/Taiwan/1/1986 (H1N1) with the previously derived reassortant X-88 (Kilbourne F169; BEI Resources NR-3589), that carried the H6 hemagglutinin (HA) gene from A/turkey/Massachusetts/3740/1975 (H6N2) and six genes encoding internal virion and non-structural proteins from A/Puerto Rico/8/1934 (H1N1). Except for the HA and NA genes, the origin of the genome segments in reassortant X-94 had not been determined prior to deposit. Nucleotide sequencing at BEI Resources of portions of the matrix (M) gene (RNA 7), nucleocapsid (NP) gene (RNA 5), and polymerase basic subunit 1 (PB1) gene (RNA 2) from NR-3642 indicates that these genes are derived from A/Taiwan/1/1986 (H1N1). The genes encoding the remaining internal proteins and the nonstructural protein may have been derived from either A/Puerto Rico/8/1934 (H1N1) or A/Taiwan/1/1986 (H1N1). Thus, it is possible that NR-3642 does not carry any A/Puerto Rico/8/1934 (H1N1)-derived genome segments.

Each vial contains approximately 1 mL of pooled allantoic fluid from specific pathogen free (SPF) embryonated chicken eggs infected with reassortant influenza A virus, A/turkey/Massachusetts/3740/1975 (HA) x A/Taiwan/1/1986 (NA) x A/Puerto Rico/8/1934 (H6N1).

Kilbourne Archive Homepage
Kilbourne/New York Medical College Archive of Influenza Virus Reassortants and Mutants
Kilbourne F174 information
Download (Word Docs):Detailed Description
File Number:F174
Virus Name:
Virus Attributes:Type A Virus. reassortant . animal virus - human virus hybrids. antigenic (HA/NA) hybrid . human NA-specific antigenic hybrid. human HA-specific antigenic hybrid
AntiserumImmunizing VirusLocationAntiserum Attributes
6488X-94B47antigenic (HA/NA) hybrid. NA Specific
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Kilbourne F174: A/turkey/Massachusetts/3740/1975 (HA) x A/Taiwan/1/1986 (NA) x A/Puerto Rico/8/1934 (H6N1), Reassortant X-94, NR-3642."
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
  • USDA APHIS VS 16-6 or 16-6A permit must be obtained and a copy of the permit must be sent to ATCC in advance of shipment. The Application Form VS 16-3 (Import controlled material import or transport organisms or vectors) must be submitted to USDA APHIS Veterinary Services to obtain the VS 16-6 or 16-6A permit.

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