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BEI Resources currently limits the total number of "Made to Order" items which can be ordered by a registrant to 10 "Made to Order" items per 6 month period. Please check the Availability Status on the items you are ordering and limit orders appropriately.
NR-44006  SARS coronavirus, Recombinant Infectious Mouse-Adapted Mutant of Urbani Strain (icSARS-CoV-MA15)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Recombinant Infectious Mouse-Adapted Mutant of Urbani Strain (icSARS-CoV-MA15)
Organism: SARS coronavirus
Biosafety Level: 3
Availability Status: In Stock
Store at: -60°C or colder
Contributor: RS Baric
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

The complete genome of SARS-CoV, MA15 has been sequenced (GenBank: FJ882957).

NR-44006 is an engineered recombinant coronavirus based on a full-length infectious clone of the SARS-CoV, Urbani genome. SARS-CoV, Urbani was serially passaged in the lungs of BALB/c mice fifteen times, and biological clones from lung homogenates were screened for lethality. One clone, MA15, which was 100% lethal in BALB/c mice within six days of inoculation, was sequenced. Six coding mutations associated with mouse adaptation and increased virulence were identified and inserted into cDNA clones that were used to construct and rescue an infectious recombinant mutant clone of SARS-CoV, Urbani. The recombinant virus was highly virulent and lethal, reproducing the phenotype of the biologically derived MA15.

Each vial contains approximately 1 mL of cell lysate and supernatant from Vero E6 (C1008) cells (ATCC ® CRL-1586™) infected with icSARS-CoV-MA15.

Additional information and tools are available at ViPR (Virus Pathogen Resource).
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: SARS Coronavirus, Recombinant Infectious Mouse-Adapted Mutant of Urbani Strain (icSARS-CoV-MA15), NR-44006."
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