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NR-44231  Human respiratory syncytial virus, A2001/3-12, Purified from HEp-2 Cells
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Description: A2001/3-12, Purified from HEp-2 Cells
Organism: Human respiratory syncytial virus
Biosafety Level: 2
Availability Status: In Stock
Store at: -80°C or colder
Contributor: ML Moore
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

Human respiratory syncytial virus (RSV), A2001/3-12 was isolated from a nasal wash from an infant with RSV bronchiolitis in Nashville, Tennessee on March 12, 2001.

A2001/3-12 is one of six clinical RSV isolates that recently were shown to induce variable disease severity, lung interleukin-13 (IL-13) levels, and gob-5 levels in BALB/cJ mice. IL-13 is a cytokine linked to mucus production and gob-5 is a calcium-activated chloride channel family member implicated in airway inflammation. Compared to mock infection, RSV A2001/3-12 infection led to relatively low levels of gob-5 in lung tissue, and no significant elevation in IL-13 expression, but did induce early weight loss and lung damage in infected mice.

NR-44231 was prepared by inoculation of HEp-2 cells (ATCC ® CCL-23™) with RSV, A2001/3-12. The virus was purified from clarified supernatant by high speed centrifugation.

Each vial contains approximately 0.5 mL of NR-44231 in TBS (0.15 M sodium chloride, 0.05 M Tris-HCl, pH 7.6).
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Human Respiratory Syncytial Virus, A2001/3-12, Purified from HEp-2 Cells, NR-44231."
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

Human respiratory syncytial virus A2001/3-12
Human respiratory syncytial virus HEp-2 Cell Supernatant, Processed Mock Infected Control
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