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NR-46417  Staphylococcus aureus, AIS 2006045
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at no cost to registered researchers.
Organism: Staphylococcus aureus
Designations: AIS 2006045
Biosafety Level: 2
Availability Status: In Stock
Store at: -60°C or colder
Contributor: J Patel
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

Staphylococcus aureus (S. aureus), strain AIS 2006045 (also referred to as VRSA-7, VRS7) was isolated in 2006 in Michigan, USA from a triceps wound of a 43-year-old female with necrotizing fasciitis of the right upper limb who had been recently treated with a five-week course of vancomycin.

S. aureus, strain AIS 2006045 is a vancomycin-resistant S. aureus (VRSA) strain and is reported to be resistant to a number of other antimicrobial agents. S. aureus, strain AIS 2006045 was deposited as positive for mec (subtype II) and vanA; negative for vanB, vanC1, vanC2, vanD, vanE, PVL and arginine catabolic mobile element (ACME); pulsed-field type USA100; spa repeats TJMBMDMGMK; Ridom spa type t002. S. aureus, strain AIS 2006045 is a USA100 isolate. USA100 isolates have the same MLST profile (ST 5) and SCCmec (subtype II) and are usually resistant to β-lactams, erythromycin and spectinomycin as well as being multiresistant to other commonly used therapeutic agents. USA100 is the most prevalent U.S health care-associated pulsed-field type and is endemic in many U.S. hospitals. S. aureus, strain AIS 2006045 is partially dependent on vancomycin for growth due to a mutation in D-alanyl:D-alanine ligase (Ddl), an enzyme involved in biosynthesis of peptidoglycans. The presence of the vanA operon compensates for the Ddl mutation by providing alternative peptidoglycans for cell wall synthesis; however, some have found that this change in the type of peptidoglycans produced renders it susceptible to oxacillin. The complete genome sequence of S. aureus, strain AIS 2006045 is available (GenBank: AHBQ00000000).

Each vial contains approximately 0.5 mL of bacterial culture in Brain Heart Infusion broth supplemented with 6 µg/mL vancomycin and 10% glycerol.
Citations: Acknowledgment for publications should read "The following reagent was provided by the Network on Antimicrobial Resistance in Staphylococcus aureus (NARSA) for distribution by BEI Resources, NIAID, NIH: Staphylococcus aureus, Strain AIS 2006045, NR-46417."
Additional Information: NARSA VRS7
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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