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NR-140   Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis
(Toxins)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis
Organism: Bacillus anthracis
Biosafety Level: 1
Availability Status: In Stock
Store at: 2°C to 8°C
Contributor: NIH - AIDS Research and Reference Reagent Program.
Comments:
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

Recombinant anthrax protective antigen (PA, 83 kDa) was produced using a plasmid licensed from the NIH. The plasmid was introduced into a non-sporulating avirulent strain of Bacillus anthracis lacking both of the wild type plasmids, pX01 and pX02. Recombinant PA was purified using conventional chromatographic techniques. The resulting purified protein lacks all other anthrax virulence factors.

Each vial contains 0.93 mg of recombinant PA.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis, NR-140."
Publications Citing
this Reagent:
Castelán-Vega, J., et al. "Reduction of Immunogenicity of Anthrax Vaccines Subjected to Thermal Stress, as Measured by a Toxin Neutralization Assay." Clin. Vaccine Immunol. 18 (2011): 349-351. PubMed: 21147935.

Clement, K. H., et al. "Vaccination of Rhesus Macaques with the Anthrax Vaccine Adsorbed Vaccine Produces a Serum Antibody Response that Effectively Neutralizes Receptor-Bound Protective Antigen in vitro." Clin. Vaccine Immunol. 17 (2010): 1753-1762. PubMed: 20739500.

Langley, W. A., et al. "Induction of Neutralizing Antibody Responses to Anthrax Protective Antigen by Using Influenza Virus Vectors: Implications for Disparate Immune System Priming Pathways." J. Virol. 84 (2010): 8300-8307. PubMed: 20504926.

Verma, A. et al. "Role of the N-Terminal Amino Acid of Bacillus anthracis Lethal Factor in Lethal Toxin Cytotoxicity and Its Effect on the Lethal Toxin Neutralization Assay." Clin. Vac. Immunol. XX (2008): 1737-1741. PubMed: 18815235.

Weiner, Z. P., et al. "Circulating Lethal Toxin Decreases the Ability of Neutrophils to Respond to Bacillus anthracis." Cell. Microbiol. 16 (2014): 504-518. PubMed: 24152301.
PERMITS
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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BEI Resources products are intended for laboratory research purposes only. They are not intended for use in humans.

While BEI Resources uses reasonable efforts to include accurate and up-to-date information on this site, BEI Resources makes no warranties or representations as to its accuracy. Citations from scientific literature and patents are provided for informational purposes only. BEI Resources does not warrant that such information has been confirmed to be accurate.


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