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NR-2619   Ricin Toxin A Subunit, from Ricinus communis
(Toxins)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Ricin Toxin A Subunit, from Ricinus communis
Organism: Ricinus communis
Biosafety Level: 1
Availability Status: In Stock
Store at: -20°C or colder
Contributor: AD O'Brien, JF Sinclair
Comments:
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

Ricin toxin is a glycoprotein that can be isolated from the seeds of the castor bean plant Ricinus communis (R. communis). Structurally, ricin toxin consists of two polypeptide chains, A and B, that are linked by a disulfide bond. The A chain of ricin toxin catalytically inactivates the eukaryotic 28S ribosomal RNA subunit resulting in the inhibition of protein synthesis and death of the cell. The ricin toxin B chain is a galactose-specific lectin that mediates the binding and delivery of the toxin to target cells. The sequence of the R. communis gene for the ricin toxin precursor protein has been reported (GenBank: X03179).

NR-2619 was purified from NR-720 ricin holotoxin by ion-exchange chromatography.

Each vial of NR-2619 contains approximately 11 µg of ricin toxin A subunit suspended in 20 mM phosphate buffer (pH 7.2).
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Ricin Toxin A Subunit, from Ricinus communis Seeds, NR-2619."
Additional Information: NR-2619 MSDS
Publications Citing
this Reagent:
Leshin, J., et al. "Characterization of Ricin Toxin Family Members from Ricinus communis." Toxicon 55 (2010): 658-661. PubMed: 19781564.
PERMITS
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

RELATED PRODUCTS
NR-720
Ricin Toxin, Isolated from Ricinus communis Seeds
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