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A recombinant form of the LF protein containing two additional amino acids at the N-terminus, a histidine (H) and a methionine (M), beyond the native N-terminal alanine (A), has been or is currently available from BEI Resources (NR-142, NR-404, NR-570, NR-723, NR-724, NR-2673, NR-4367, NR-4368). This form of the protein has been recently designated LF-HMA by the manufacturer and is also produced in Bacillus anthracis. Note: LF-A has been reported to have 3-fold higher potency than LF-HMA in cell culture cytotoxicity assays and in rat lethality studies. LF is a zinc-dependent metalloprotease which cleaves the amino terminus of signaling proteins of the mitogen-activated protein kinase family (MAPKK), destroying their ability to signal. In vivo, recombinant LF binds to a cleaved form of recombinant protective antigen (PA), and is transported by PA into the cytosol of the macrophage where LF exerts its pathogenic effect. Each vial contains approximately 0.1 mg (lyophilized) of recombinant LF-A from Bacillus anthracis.
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For more information on the necessary compliance requirements associated with the biological materials provided by BEI Resources, please select this link: Compliance Requirements.