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A recombinant form of the LF protein containing
two additional amino acids at the N-terminus, a histidine (H) and a methionine
(M), beyond the native N-terminal alanine (A), has been or is currently
available from BEI Resources (NR-142, NR-404, NR-570, NR-723, NR-724, NR-2673,
NR-4367, NR-4368). This form of the protein has been recently designated
LF-HMA by the manufacturer and is also produced in Bacillus anthracis. Note: LF-A has been reported to have 3-fold higher
potency than LF-HMA in cell culture cytotoxicity assays and in rat lethality
LF is a zinc-dependent metalloprotease which
cleaves the amino terminus of signaling proteins of the mitogen-activated
protein kinase family (MAPKK), destroying their ability to signal. In
vivo, recombinant LF binds to a cleaved form of recombinant protective
antigen (PA), and is transported by PA into the cytosol of the macrophage where
LF exerts its pathogenic effect. Each
vial contains approximately 0.1 mg (lyophilized) of recombinant LF-A from Bacillus
If shipping to the U.S. State of Hawaii, you must provide either an import permit or documentation stating that an import permit is not required. We cannot ship this item until we receive this documentation. Contact the Hawaii Department of Agriculture (HDOA), Plant Industry Division, Plant Quarantine Branch to determine if an import permit is required.
When applying for permits and forms please:
Do NOT reference BEI Resources or ATCC Catalog Numbers in the Material Description
fields found on the permits and/or forms.
Make sure your name and address on the permit applications and/or forms are exactly
as they appear on your BEI Resources registration.
Information about permits is provided as a courtesy to BEI Resources customers.
While we use reasonable efforts to include accurate and up-to-date information on
this page, we make no warranties or representation as to its accuracy.
For more information on the necessary compliance requirements associated with the
biological materials provided by BEI Resources, please select this link: Compliance Requirements.
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