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BEI Resources currently limits the total number of "Made to Order" items which can be ordered by a registrant to 10 "Made to Order" items per 6 month period. Please check the Availability Status on the items you are ordering and limit orders appropriately.
NR-4478   Shiga Toxin Type 2, Recombinant from Escherichia coli
(Toxins)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Shiga Toxin Type 2, Recombinant from Escherichia coli
Organism: Escherichia coli
Biosafety Level: 2
Availability Status: In Stock
Store at: -20°C or colder
Contributor: AD O'Brien, JF Sinclair
Comments:
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment. 

Recombinant Shiga toxin type 2 was expressed in Escherichia coli (E. coli) and purified by affinity chromatography.

The sequences of Stx2 for multiple strains of E. coli have been determined and the crystal structure of Stx2 from E. coli has been resolved (PMB: 1R4P).

Each vial of NR-4478 contains approximately 10 µg of Shiga toxin type 2 suspended in PBS.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Shiga Toxin Type 2, Recombinant from Escherichia coli, NR-4478."
Additional Information: NR-4478 Safety Data Sheet
Publications Citing
this Reagent:
Lentz, E. K., et al. "Role of Tumor Necrosis Factor alpha in Disease Using a Mouse Model of Shiga Toxin-Mediated Renal Damage." Infect. Immun. 78 (2010): 3689-3699. PubMed: 20605983.

Lentz, E. K., et al. "Differential Response of the Human Renal Proximal Tubular Epithelial Cell Line HK-2 to Shiga Toxin Types 1 and 2." Infect. Immun. 79 (2011): 3527-3540. PubMed: 21708996.

Stearns-Kurosawa, D., et al. "Distinct Physiologic and Inflammatory Responses Elicited in Baboons after Challenge with Shiga Toxin Type 1 or 2 from Enterohemorrhagic Escherichia coli." Infect. Immun. 78 (2010): 2497-2504. PubMed: 20308301.

Stearns-Kurosawa, D. J., et al. "Rescue from Lethal Shiga Toxin 2-Induced Renal Failure with a Cell-Permeable Peptide." Pediat. Nephrol. 26 (2011): 2031-2039. PubMed: 21603905.

Stearns-Kurosawa, D. J., et al. "Distinct Renal Pathology and a Chemotactic Phenotype after Enterohemorrhagic E. coli Shiga Toxins in Non-Human Primate Models of Hemolytic Uremic Syndrome." Am. J. Path. 182 (2013): 1227-1238. PubMed: 23402998.

Stolfa, G. and G. B. Koudelka. "Entry and Killing of Tetrahymena thermophila by Bacterially Produced Shiga Toxin." mBio. 4 (2013): e00416-00412. PubMed: 23269826.
PERMITS
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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BEI Resources products are intended for laboratory research purposes only. They are not intended for use in humans.

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