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NR-4671   Ricin Toxoid, Chemically Inactivated from Ricinus communis
(Toxins)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Ricin Toxoid, Chemically Inactivated from Ricinus communis
Organism: Ricinus communis
Biosafety Level: 1
Availability Status: In Stock
Store at: -20°C or colder (Note: For long term storage, store at -80°C or colder.)
Contributor: AD O'Brien, JF Sinclair
Comments:
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

NR-4671 was generated by formaldehyde treatment of the purified, glycosylated ricin holotoxin. Ricin toxoid is non-toxic.

Ricin toxin is a glycoprotein that can be isolated from the seeds of the castor bean plant Ricinus communis (R. communis). Structurally, ricin toxin consists of two polypeptide chains, A and B, that are linked by a disulfide bond. The A-chain of ricin toxin catalytically inactivates the eukaryotic 28S ribosomal RNA subunit resulting in the inhibition of protein synthesis and death of the cell. The ricin toxin B-chain is a galactose-specific lectin that mediates the binding and delivery of the toxin to target cells. The sequence of the R. communis gene for the ricin toxin precursor protein has been reported (GenBank: X03179).

Each vial of NR-4671 contains approximately 1 mg of ricin toxoid suspended in buffer. NR-4671 lots 61632757 and 57680183 contained approximately 1 mg of ricin toxoid suspended in 10 mM Tris buffer (pH ~ 8.0).

NR-4671 reacts with polyclonal antiserum to ricin holotoxin as determined by western blot. In addition, NR-4671, lot 57680183, is reported to react specifically with monoclonal antibodies to ricin A- and B-chains (BEI Resources NR-843 and NR-842).
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Ricin Toxoid, Chemically Inactivated from Ricinus communis , NR-4671."
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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