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NR-4673   Epsilon Toxoid (Chemically Inactivated Epsilon Toxin) from Clostridium perfringens
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Description: Epsilon Toxoid (Chemically Inactivated Epsilon Toxin) from Clostridium perfringens
Organism: Clostridium perfringens
Biosafety Level: 1
Availability Status: In Stock
Store at: -20°C or colder (Note: For long term storage, store at -80°C or colder.)
Contributor: AD O'Brien, JF Sinclair
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

NR-4673 is a preparation of epsilon toxin which was purified from culture supernatants of Clostridium perfringens (C. perfringens) and inactivated by treatment with 1% formaldehyde. Unreacted formaldehyde was removed by dialysis against PBS.

Epsilon toxin is produced by strains of C. perfringens that inhabit the intestinal tract of sheep and lambs. Intoxication results in enterotoxemia and neurological disorders and is usually fatal in certain livestock. The sequence of the gene for the epsilon toxin precursor protein has been reported (GenBank: M95206 and M80837). The structure of epsilon protoxin has been solved (PDB: 1UYJ).

Each vial of NR-4673 contains approximately 0.1 mg of epsilon toxoid in PBS.

NR-4673 is reactive with polyclonal immunoglobulin G produced by immunization of rabbits with peptides that correspond to distinct internal regions of the full-length epsilon toxin (BEI Resources NR-865) on western blots.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Epsilon Toxoid (Chemically Inactivated Epsilon Toxin) from Clostridium perfringens, NR-4673."
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

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