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NR-742   Ricin Toxin, Isolated from Ricinus communis Seeds
(Toxins)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Ricin Toxin, Isolated from Ricinus communis Seeds
Organism: Ricinus communis
Biosafety Level: 2
Availability Status: In Stock
Store at: 2°C to 8°C
Contributor: AD O'Brien, JF Sinclair
Comments:

Extremely toxic - any exposure may be fatal! Exercise caution! Do not lyophilize!

Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

NR-742 was isolated from Ricinus communis (R. communis) seeds and purified by ion exchange chromatography. The signal sequence was cleaved from the protein and the expected molecular weight is 60.2 kDa. The sequence for the R. communis gene for the ricin toxin precursor protein has been reported (GenBank: XP_002534649).

Ricin toxin is a glycoprotein isolated from the seeds of R. communis, the castor bean plant. Ricin toxin consists of two polypeptide chains, A and B, linked by a disulfide bond. The A chain catalytically inactivates the eukaryotic 28S ribosomal RNA subunit, resulting in the inhibition of protein synthesis and death of the cell. The B chain is responsible for receptor binding and delivery of the toxin to the target cell.

Each vial of NR-742 contains approximately 1 mg of ricin toxin suspended in phosphate buffered saline (PBS).

For information about toxin amounts excluded from CDC Select Agent regulations, click here.

Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Ricin Toxin, Isolated from Ricinus communis Seeds, NR-742."
Additional Information: NR-742 Safety Data Sheet
PERMITS
For a list of permits that may be required for shipping this product and to set the permit information preferences; please select a country from the drop down below.

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
  • Customer Acknowledgement of Toxin Threshold Limits, BEI Resources form required for distribution. The APHIS/CDC Form 2 is only required if more than the threshold quantity for this specific toxin is ordered.
  • Select Agents require facility registration for specific agents with CDC and completion of APHIS/CDC Form 2. For information about toxin amounts excluded from CDC Select Agent regulations, click here.

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