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BEI Resources currently limits the total number of "Made to Order" items which can be ordered by a registrant to 10 "Made to Order" items per 6 month period. Please check the Availability Status on the items you are ordering and limit orders appropriately.
NR-856   Epsilon Protoxin, from Clostridium perfringens, Strain 34 (Type B)
Price: All BEI Resources products are provided
at no cost to registered researchers.
Description: Epsilon Protoxin, from Clostridium perfringens, Strain 34 (Type B)
Organism: Clostridium perfringens
Biosafety Level: 2
Availability Status: In Stock
Store at: -80°C or colder
Contributor: AD O'Brien, JF Sinclair
Quantity limit per order for this item is 1. This item can be ordered twice a year. Orders over this limit will be sent to NIAID for approval before shipment.

Epsilon protoxin was purified from culture supernatants of Clostridium perfringens (C. perfringens), strain 34 (type B) (ATCC ® 3626™). The protein is suitable for western blots or can be treated with trypsin to generate the active toxin for cytotoxicity assays.

Epsilon toxin is produced by strains of C. perfringens that inhabit the intestinal tract of sheep and lambs. Intoxication results in enterotoxemia and neurological disorders and is usually fatal in certain livestock. The sequence of the gene for the epsilon toxin precursor protein has been reported (GenBank: M95206). The structure of epsilon protoxin has been solved (PDB: 1UYJ).

NR-856 reacts with polyclonal IgG antibody produced by immunization of rabbits with peptides that correspond to distinct internal regions of the full-length epsilon toxin (BEI Resources NR-865).

Each vial of NR-856 contains approximately 0.25 mg of epsilon protoxin suspended in 10 mM phosphate buffer (pH 7.4).

For information about toxin amounts excluded from CDC Select Agent regulations, click here.
Citations: Acknowledgment for publications should read "The following reagent was obtained through BEI Resources, NIAID, NIH: Epsilon Protoxin, from Clostridium perfringens, Strain 34 (Type B), NR-856."
Additional Information: NR-856 Safety Data Sheet
Publications Citing
this Reagent:
Garcia, J., et al. "Epsilon Toxin is Essential for the Virulence of Clostridium perfringens Type D Infection in Sheep, Goats, and Mice." Infect. Immun. 81 (2013): 2405-2414.  PubMed:  23630957.

Rumah, K. R., et al. "Isolation of Clostridium perfringens Type B in an Individual at First Clinical Presentation of Multiple Sclerosis Provides Clues for Environmental Triggers of the Disease." PloS One 8 (2013): e76359.  PubMed:  24146858.
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  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.

Polyclonal Anti-Epsilon Toxin from Clostridium perfringens (immunoglobulin G, Rabbit)
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BEI Resources products are intended for laboratory research purposes only. They are not intended for use in humans.

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