Welcome to MR4, now part of BEI Resources     

The Malaria Research and Reference Reagent Resource Center (MR4) has provided quality controlled malaria reagents, protocols and technical support for the international research community since 1998. Supported by the National Institute of Allergy and Infectious Diseases (NIAID) and now part of the NIAID BEI Resources, MR4 acquires, authenticates, preserves and distributes parasites, mosquito vectors and associated biological and molecular reagents. MR4 materials are provided at no cost to registered researchers (additional shipping and handling charges may apply).

Artemisinin Resistant Plasmodium falciparum Cambodia Isolates

Artemisinin resistant in vitro culture-adapted clinical isolates from Didier Menard at the Institut Pasteur du Cambodge have been deposited in MR4 for use in the ring-stage survival assay (RSA) and other screening applications. Six culture isolates, with DHA treated RSA values ranging from 0.1% to >68%, are now available. Genomic DNAs from these isolates are set for release in the near future.

Looking for Non-Mosquito Vectors?

BEI Resources houses a new Vector Resources collection including non-malaria mosquitoes and other arthropod vectors of infectious disease.

Plasmodium falciparum Senegal and Tanzania Field Isolates released

New Plasmodium falciparum field isolates obtained from villages near Dakar, Senegal are from patient populations that were recently exposed to multiple, changing drug regimens due to the emergence of clinical resistance to traditional drugs. The parasites exhibit diverse genetic barcodes and antimalarial drug sensitivity profiles (Park et al., PNAS, 109: 13052–13057, 2012). MRA-1169, Plasmodium falciparum 02000708 Tanzania, a clinical isolate from Morogoro, has also become available in the catalog. Click here to view isolates.

MR4 is Now Part of BEI Resources

The NIAID MR4 program has been your go-to resource for malaria repository reagents for nearly 12 years. As part of the integration and consolidation of NIAID specalized programs of biological materials, MR4 is now part of NIAID centralized research material repository, BEI Resources.  Click here to learn more about BEI Resources.

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