TARGET Research Results
Details
DescriptionPPE FAMILY PROTEIN
Accession numberRv1800
Gene namePPE28
Gene length1968
Protein length655
Coordinates2039453..2041420
Orientation+
Molecular mass67067.22
Isoelectric point4.24

Database Crossreferences
Deletion Mutant Phenotype
in-vivoguinea pig
 mouse
 rabbit

in-vitroHBMEC
 macrophage

Mutant Survival in DeADMAn (Lamichhane et al., 2005)*

Strain NamePhenotype (Mouse)
JHU1800-1391[no data]
JHU1800-1288[no data]
JHU1800-1420[no data]
JHU1800-1192[no data]
JHU1800-1855[no data]
JHU1800-469[no data]
JHU1800-1717[no data]
JHU1800-714Not-Attenuated
 

CDC1551 Homolog
ORFMT1849
Essentiality Prediction
Sassetti et al, 2003*[no data]

JHU Transposon Mutant(s) Available
NameMT#Rv#POIGene LengthAvailable from BEI
JHU1800-1391MT1849Rv180013911968yes
JHU1800-1288MT1849Rv180012881968no (will be available later)
JHU1800-1420MT1849Rv180014201968yes
JHU1800-1192MT1849Rv180011921968no (will be available later)
JHU1800-469MT1849Rv18004691968yes
JHU1800-1717MT1849Rv180017171968no (will be available later)
  
For a list of currently available mutants, please visit BEI's transposon mutant webpage.

If we have not disrupted your gene using random mutagenesis, we may be able to create a knockout mutant for you.

References
Lamichhane, G., M. Zignol, N. J. Blades, D. E. Geiman, A. Dougherty, J. Grosset, K. W. Broman, and W. R. Bishai. (2003) Proc. Natl. Acad. Sci. USA 100:7213-7218. [Abstract/Free Full Text]
Sassetti, C. M., Boyd, D. H. & Rubin, E. J. (2003) Proc. Natl. Acad. Sci. USA 100:12989-12994. [Abstract/Free Full Text]
Lamichhane G, Tyagi S, Bishai WR (2005) Infect Immun. Apr;73(4):2533-40.
[Abstract/Free Full Text]