Parechovirus A (formerly Human parechovirus or HPeV) is an emerging infection of public health concern among pediatric populations in North America. HPeV belongs to the family Picornaviridae and is currently divided into 19 genotypes. Parechovirus A type 3 (HPeV-3) is clinically the most important genotype as it has been associated with more severe clinical manifestations in the form of sepsis-like and central nervous system (CNS) illnesses, particularly in neonates and infants. HPeV3 was initially isolated in 1999 from a patient in Japan and has been detected with increasing frequency over the last decade in Asia, Europe, Canada, South America, and more recently, in the United States. HPeV3 is the most common single cause of aseptic meningitis/ meningoencephalitis in infants less than 90 days old in North America. BEI Resources now offers two HPeV3 isolates from the United States, including one from the 2014 outbreak in Missouri.
Image: Parechovirus (ViperDB)